Biotin complexes for treatment and diagnosis of Alzheimer'S disease
First Claim
Patent Images
1. A composition comprising a biotin moiety and a siRNA moiety, wherein the siRNA moiety comprises a nucleotide of SEQ ID NO:
- 2 or a nucleic acid that has at least 95% sequence homology with SEQ ID NO;
2.
1 Assignment
0 Petitions
Accused Products
Abstract
Described herein are compositions and methods for treating or imaging Alzheimer'"'"'s disease (AD). The compositions comprise a biotin moiety and a siRNA moiety, without the need for a targeting agent such as an antibody, avidin, or streptavidin. In certain embodiments, the compositions further comprise a diagnostic agent.
-
Citations
12 Claims
-
1. A composition comprising a biotin moiety and a siRNA moiety, wherein the siRNA moiety comprises a nucleotide of SEQ ID NO:
- 2 or a nucleic acid that has at least 95% sequence homology with SEQ ID NO;
2. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12)
- 2 or a nucleic acid that has at least 95% sequence homology with SEQ ID NO;
Specification