Device and method for removal of blood-borne pathogens, toxins and inflammatory cytokines
First Claim
1. A system for broad-spectrum whole-blood extracorporeal separation of blood-borne factors of interest comprising:
- an extracorporeal solid substrate or cartridge, wherein the solid substrate or cartridge is a broad-spectrum, anti-thrombogenic cartridge having a solid substrate, which is essentially nonporous, comprising covalently-bonded, end-point attached heparin on a high-surface-area polymer substrate;
one or more biosensors, wherein the one or more biosensors is an extracorporeal sensor for a nitric oxide biomarker; and
an extracorporeal pump for the extracorporeal circulation of blood, and a patient monitor, wherein the system extracorporeally separates blood-borne factors of interest from whole blood.
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Abstract
The present invention is directed to an integrated system and a method for utilizing the system to detect and remove blood-borne factors of interest, such as pathogens and/or toxins and/or cytokines, from blood or serum (blood) by contacting the blood with a solid, essentially nonporous substrate which has been surface treated with molecules or chemical groups (the adsorbent media or media) having a binding affinity for the pathogens and/or toxins to be removed (the adsorbents). The invention can be used to remove virulence factors, e.g. toxins, that are released from various pathogens. In one aspect, the invention is for the treatment of sepsis and infection, such as infections associated with battle field trauma.
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Citations
20 Claims
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1. A system for broad-spectrum whole-blood extracorporeal separation of blood-borne factors of interest comprising:
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an extracorporeal solid substrate or cartridge, wherein the solid substrate or cartridge is a broad-spectrum, anti-thrombogenic cartridge having a solid substrate, which is essentially nonporous, comprising covalently-bonded, end-point attached heparin on a high-surface-area polymer substrate; one or more biosensors, wherein the one or more biosensors is an extracorporeal sensor for a nitric oxide biomarker; and an extracorporeal pump for the extracorporeal circulation of blood, and a patient monitor, wherein the system extracorporeally separates blood-borne factors of interest from whole blood. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10)
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11. An extracorporeal method for broad-spectrum whole-blood separation of blood-borne factors of a patient, comprising:
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(a) detecting the presence or amount of a blood-borne factor of interest using an extracorporeal biosensor, (b) bringing a sample of blood in contact using convection transport with a broad-spectrum, anti-thrombogenic extracorporeal cartridge having a solid substrate, which is essentially nonporous, comprising covalently-bonded, end-point attached heparin on a high-surface-area polymer substrate, and (c) separating the sample from said broad-spectrum, anti-thrombogenic cartridge whereby said blood-borne factor is at least partially retained on said extracorporeal cartridge and the removed sample has a reduced amount of blood-borne factor. - View Dependent Claims (12, 13, 14, 15, 16, 17, 18, 19, 20)
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Specification