Medical unit dose container

• US 10,537,692 B2
• Filed: 04/28/2014
• Issued: 01/21/2020
• Est. Priority Date: 04/28/2013
• Status: Active Grant

• Current Assignee: Woodward Specialty LLC
• Original Assignee: Impel Neuropharma Inc.
• Inventors: Hoekman, John D., Brunelle, Alan, Kohring, Craig, Fuller, Christopher
• Primary Examiner(s): Stuart, Colin W
• Application Number:
  US14/787,455
• Publication Number:
  US 20160101245A1
• Time in Patent Office: 2,094 Days
• Field of Search: 12820014, 12820023
• CPC Class Codes: A61M 11/006 operated by applying mechanical pressure to the liquid to be sprayed or atomised
• CPC Class Codes: A61M 11/02 operated by air or other gas pressure applied to the liquid or other product to be sprayed or atomised sprayers for horticulture A01G, A01H; killing insects A01M; air humidifying by nozzles F24F6/14, F24F6/18; cooling by spraying F28B, F28C
• CPC Class Codes: A61M 15/0001 Details of inhalators; Constructional features thereof
• CPC Class Codes: A61M 15/0028 using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
• CPC Class Codes: A61M 15/003 using capsules, e.g. to be perforated or broken-up
• CPC Class Codes: A61M 15/0033 Details of the piercing or cutting means
• CPC Class Codes: A61M 15/0035 Piercing means
• CPC Class Codes: A61M 15/0036 hollow piercing means
• CPC Class Codes: A61M 15/004 with fixed piercing or cutting means
• CPC Class Codes: A61M 15/0086 Inhalation chambers
• CPC Class Codes: A61M 15/009 using medicine packages with incorporated spraying means, e.g. aerosol cans pocket atomiser of the injector type A61M11/08
• CPC Class Codes: A61M 15/08 Inhaling devices inserted into the nose
• CPC Class Codes: A61M 2207/00 Methods of manufacture, assembly or production
• CPC Class Codes: A61M 2210/0618 Nose

Abstract

A unit dose container for the containment of an intranasal formulation for use with the POD device.

Claims

1. A device for delivering a compound to an olfactory region of a nasal cavity comprising:

a housing body, the housing body configured to hold a canister configured to contain a propellant,

a tip configured to removably couple to the housing body of the device, the tip comprising;

a container cavity configured to receive a unit dose container, the unit dose container configured to contain the compound,

a diffuser positioned across an opening of the container cavity, the diffuser configured to be in communication with the canister such that propellant exiting the canister travels through the diffuser,

a nozzle in communication with the container cavity, and

a puncture member that is configured to, upon coupling the tip to the housing body, puncture an end of the unit dose container such that the unit dose container is in communication with the diffuser, and following contact with the diffuser, the diffused propellant contacts the compound contained in the unit dose container,

wherein the device is capable of delivering the compound to the olfactory region of the nasal cavity.

2. The device of claim 1, further comprising an additional puncture member, wherein the additional puncture member comprises a front puncture member positioned on the tip.

3. The device of claim 1 wherein the puncture member has an angle of puncture between 15 degrees and 90 degrees, inclusive.

4. The device of claim 1 wherein the puncture member further comprises a side orifice.

5. The device of claim 1 wherein the compound is an intranasal formulation.

6. The device of claim 1 wherein the end of the unit dose container further includes a rubber stopper or a foil seal or combinations thereof.

7. The device of claim 1 wherein the end of the unit dose container includes a puncture area.

8. The device of claim 7 wherein the puncture area is a dimple.

9. The device of claim 1 wherein the puncture member is composed of metal or a polymer or combinations thereof.

10. The device of claim 1 wherein the unit dose container is composed of a polymer or glass.

11. The device of claim 10 where the polymer is polyethylene, ethyl vinyl alcohol copolymer, low-density polyethylene, high-density polyethylene, or polypropylene.

12. The device of claim 1 wherein the unit dose container is cylinder-shaped, cone-shaped, tube-shaped, rectangular-shape, polygonal, hexagonal, or oval-shaped.

13. The device of claim 1 wherein the unit dose container is formed by injection molding, blow molding, injection blow molding, or a blow-fill-seal process.

14. The device of claim 1 wherein the diffuser is a frit.

15. The device of claim 1 further comprising a connection channel having a first end and a second end, where the first end is coupled to the canister and the second end is coupled to the diffuser, wherein a diameter of the diffuser across the opening of the container cavity is greater than a diameter of the connection channel.

16. The device of claim 1, wherein the puncture member comprises a rear puncture member positioned on the housing body, the device further comprising a front puncture member positioned on the tip, wherein each puncture member is configured to puncture a respective end of the unit dose container.

17. The device of claim 1 wherein the puncture member comprises a hollow channel for delivery of the propellant into the unit dose container.

18. The device of claim 1 wherein the puncture member is composed of a porous material for delivery of the propellant into the unit dose container.

19. The device of claim 1 wherein the tip is configured to translate relative to the housing body.

20. The device of claim 1 wherein the tip and the housing body each have respective threaded interfaces that are configured to mate.