Methods and systems for detecting health conditions by imaging portions of the eye, including the fundus

• US 10,539,794 B2
• Filed: 09/19/2016
• Issued: 01/21/2020
• Est. Priority Date: 03/16/2015
• Status: Active Grant

• Current Assignee: Magic Leap, Inc.
• Original Assignee: Magic Leap, Inc.
• Inventors: Samec, Nicole Elizabeth, Macnamara, John Graham, Harrises, Christopher M., Schowengerdt, Brian T., Abovitz, Rony, Baerenrodt, Mark
• Primary Examiner(s): Tseng, Charles
• Application Number:
  US15/269,557
• Publication Number:
  US 20170000342A1
• Time in Patent Office: 1,219 Days
• CPC Class Codes: A61B 2562/0204 Acoustic sensors
• CPC Class Codes: A61B 2562/0219 Inertial sensors, e.g. accelerometers, gyroscopes, tilt switches
• CPC Class Codes: A61B 2562/0247 Pressure sensors
• CPC Class Codes: A61B 3/0008 provided with illuminating means A61B3/117 takes precedence; goniolenses used for laser treatment A61F9/009; illuminating means for optical instruments G02B27/00
• CPC Class Codes: A61B 3/0025 characterised by electronic signal processing, e.g. eye models
• CPC Class Codes: A61B 3/005 Constructional features of the display
• CPC Class Codes: A61B 3/022 for testing contrast sensitivity
• CPC Class Codes: A61B 3/024 for determining the visual field, e.g. perimeter types
• CPC Class Codes: A61B 3/028 for testing visual acuity; for determination of refraction, e.g. phoropters
• CPC Class Codes: A61B 3/0285 Phoropters
• CPC Class Codes: A61B 3/032 Devices for presenting test symbols or characters, e.g. test chart projectors A61B3/036 takes precedence
• CPC Class Codes: A61B 3/036 for testing astigmatism
• CPC Class Codes: A61B 3/063 for testing light sensitivity, i.e. adaptation
• CPC Class Codes: A61B 3/066 for testing colour vision
• CPC Class Codes: A61B 3/08 for testing binocular or stereoscopic vision, e.g. strabismus
• CPC Class Codes: A61B 3/085 for testing strabismus
• CPC Class Codes: A61B 3/10 Objective types, i.e. instruments for examining the eyes independent of the patients' perceptions or reactions
• CPC Class Codes: A61B 3/1005 for measuring distances inside the eye, e.g. thickness of the cornea A61B3/11 takes precedence
• CPC Class Codes: A61B 3/101 for examining the tear film
• CPC Class Codes: A61B 3/1015 for wavefront analysis
• CPC Class Codes: A61B 3/102 : for optical coherence tomography [OCT]
• CPC Class Codes: A61B 3/1035 : for measuring astigmatism testing astigmatism A61B3/036
• CPC Class Codes: A61B 3/113 : for determining or recording eye movement
• CPC Class Codes: A61B 3/12 : for looking at the eye fundus, e.g. ophthalmoscopes A61B3/13 takes precedence
• CPC Class Codes: A61B 3/1216 : for diagnostics of the iris
• CPC Class Codes: A61B 3/1241 : specially adapted for observation of ocular blood flow, e.g. by fluorescein angiography
• CPC Class Codes: A61B 3/13 : Ophthalmic microscopes
• CPC Class Codes: A61B 3/14 : Arrangements specially adapted for eye photography apparatus or arrangements for taking photographs per se G03B
• CPC Class Codes: A61B 3/165 : Non-contacting tonometers
• CPC Class Codes: A61B 5/0059 : using light, e.g. diagnosis by transillumination, diascopy, fluorescence A61B5/0093, A61B5/1455, A61B5/02416 and A61B5/0261 take precedence
• CPC Class Codes: A61B 5/0066 : Optical coherence imaging
• CPC Class Codes: A61B 5/0077 : Devices for viewing the surface of the body, e.g. camera, magnifying lens
• CPC Class Codes: A61B 5/01 : Measuring temperature of body parts ; Diagnostic temperature sensing, e.g. for malignant or inflamed tissue clinical contact thermometers G01K13/20
• CPC Class Codes: A61B 5/12 : Audiometering
• CPC Class Codes: A61B 5/14532 : for measuring glucose, e.g. by tissue impedance measurement
• CPC Class Codes: A61B 5/1455 : using optical sensors, e.g. spectral photometrical oximeters
• CPC Class Codes: A61B 5/14555 : specially adapted for the eye fundus
• CPC Class Codes: A61B 5/361 : Detecting fibrillation
• CPC Class Codes: A61B 5/369 : Electroencephalography [EEG] devices for psychotechnics A61B5/16
• CPC Class Codes: A61B 5/398 : Electrooculography [EOG], e.g. detecting nystagmus; Electroretinography [ERG]
• CPC Class Codes: A61B 5/6803 : Head-worn items, e.g. helmets, masks, headphones or goggles
• CPC Class Codes: A61B 8/10 : Eye inspection
• CPC Class Codes: A61B 8/461 : Displaying means of special interest
• CPC Class Codes: A61F 2007/0004 : Eyes or part of the face surrounding the eyes
• CPC Class Codes: A61F 2007/004 : Hip
• CPC Class Codes: A61F 2009/00863 : Retina
• CPC Class Codes: A61F 9/0026 : Ophthalmic product dispenser attachments to facilitate positioning near the eye
• CPC Class Codes: A61H 2201/165 : Wearable interfaces
• CPC Class Codes: A61M 2021/0022 : by the tactile sense, e.g. vibrations
• CPC Class Codes: A61M 2021/0027 : by the hearing sense
• CPC Class Codes: A61M 2021/0066 : with heating or cooling
• CPC Class Codes: A61M 21/02 : for inducing sleep or relaxation, e.g. by direct nerve stimulation, hypnosis, analgesia for massage A61H; electrotherapy A61N, e.g. applying alternating or intermittent electric currents for producing anaesthesia A61N1/36021
• CPC Class Codes: A61M 2205/3375 : Acoustical, e.g. ultrasonic, measuring means
• CPC Class Codes: A61M 2205/507 : Head Mounted Displays [HMD]
• CPC Class Codes: A61N 2005/0648 : the light being directed to the eyes
• CPC Class Codes: G02B 2027/0138 : comprising image capture systems, e.g. camera
• CPC Class Codes: G02B 2027/014 : comprising information/image processing systems
• CPC Class Codes: G02B 2027/0185 : Displaying image at variable distance
• CPC Class Codes: G02B 21/0032 : Optical details of illumination, e.g. light-sources, pinholes, beam splitters, slits, fibers G02B21/0036 - G02B21/008; means for illumination of specimens in general G02B21/06
• CPC Class Codes: G02B 27/0093 : with means for monitoring data relating to the user, e.g. head-tracking, eye-tracking
• CPC Class Codes: G02B 27/0172 : characterised by optical features
• CPC Class Codes: G02B 27/0179 : Display position adjusting means not related to the information to be displayed
• CPC Class Codes: G02C 7/027 : considering wearer's parameters
• CPC Class Codes: G06T 19/006 : Mixed reality object pose determination, tracking or camera calibration for mixed reality G06T7/00
• CPC Class Codes: G06T 2207/10024 : Color image
• CPC Class Codes: G06T 2207/10148 : Varying focus
• CPC Class Codes: G06T 2207/10152 : Varying illumination
• CPC Class Codes: G06T 2207/30041 : Eye; Retina; Ophthalmic
• CPC Class Codes: G16H 20/17 : delivered via infusion or injection
• CPC Class Codes: G16H 40/63 : for local operation
• CPC Class Codes: G16H 40/67 : for remote operation
• CPC Class Codes: G16H 50/20 : for computer-aided diagnosis, e.g. based on medical expert systems

Abstract

Configurations are disclosed for a health system to be used in various healthcare applications, e.g., for patient diagnostics, monitoring, and/or therapy. The health system may comprise a light generation module to transmit light or an image to a user, one or more sensors to detect a physiological parameter of the user'"'"'s body, including their eyes, and processing circuitry to analyze an input received in response to the presented images to determine one or more health conditions or defects.

Claims

1. A wearable augmented reality device comprising:

an augmented reality head-mounted ophthalmic system comprising an augmented reality display platform configured to pass light from the world into an eye of a wearer wearing the augmented reality head-mounted ophthalmic system, wherein the augmented reality head-mounted ophthalmic display platform comprises;

a waveguide stack comprising a plurality of waveguides,

wherein one or more waveguides of the plurality of waveguides are configured to output image light with a different amount of wavefront divergence than one or more other waveguides of the plurality of waveguides, wherein different amounts of wavefront divergence from the plurality of waveguides correspond to different depth planes;

a light source configured to illuminate a portion of the wearer'"'"'s eye; and

an imaging system configured to capture an image of the illuminated portion of the wearer'"'"'s eye,

wherein the augmented reality head-mounted ophthalmic system is configured to monitor health of the wearer'"'"'s eye and detect abnormalities of the wearer'"'"'s eye based on the image.

2. The device of claim 1, wherein the light source is a variable focus light source configured to project a beam of light into the wearer'"'"'s eye and to focus the beam of light at varying depths in the wearer'"'"'s eye.

3. The device of claim 1, wherein the light source is a fiber scanning display, and wherein the fiber scanning display is configured to project a beam of light of a particular focus to the portion of the wearer'"'"'s eye.

4. The device of claim 3, wherein the fiber scanning display comprises an imaging system, wherein the fiber scanning display is configured to project the beam of light and to capture the image of the illuminated portion of the wearer'"'"'s eye.

5. The device of claim 4, wherein the imaging system is an eye tracking camera.

6. The device of claim 1, further comprising an electronic hardware processor configured to analyze the image to detect abnormalities of the wearer'"'"'s eye or health problems by matching a known pattern with the image.

7. The device of claim 6, wherein a memory of the augmented reality head-mounted ophthalmic system is pre-loaded with known patterns indicative of health problems.

8. The device of claim 6, wherein the electronic hardware processor is remote from the augmented reality head-mounted ophthalmic system.

9. The device of claim 1, further comprising an adaptable optics element.

10. The device of claim 9, wherein the light source is configured to project a beam of light into a portion of the wearer'"'"'s eye, and wherein the adaptable optics element is configured to selectively project the beam of light to a portion of the wearer'"'"'s eye.

11. The device of claim 10, wherein the adaptable optics element comprises a variable focus element.

12. The device of claim 1, wherein the light source is configured to project a beam of light on a fundus of the wearer'"'"'s eye.

13. The device of claim 12, wherein the projected beam of light comprises white light.

14. The device of claim 12, wherein the projected beam of light comprises light of one or more wavelengths corresponding to a selected color.

15. The device of claim 14, wherein the projected beam of light has a wavelength in one of a red, green or blue spectral region of the visible spectrum of light.

16. The device of claim 14, wherein the projected beam of light is in a range of wavelengths in the infrared spectrum of light.

17. The device of claim 1, wherein the imaging system is configured to capture an image of at least a portion of the fundus of the wearer'"'"'s eye.

18. The device of claim 1, wherein the imaging system is configured to capture an image of at least a portion of the retina of the wearer'"'"'s eye.

19. The device of claim 1, wherein the imaging system is configured to capture images corresponding to different depths in the wearer'"'"'s eye.

20. The device of claim 1, wherein each waveguide of the plurality of waveguides has an associated diffractive out-coupling optical element.