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Modulation of a response signal to distinguish between analyte and background signals

  • US 10,542,918 B2
  • Filed: 10/23/2013
  • Issued: 01/28/2020
  • Est. Priority Date: 10/23/2013
  • Status: Active Grant
First Claim
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1. A method, comprising:

  • detecting an analyte response signal transmitted from within a lumen of subsurface vasculature inside a body, wherein the analyte response signal is indicative of interaction of functionalized particles with one or more target analytes present in blood circulating in the subsurface vasculature, wherein the functionalized particles each comprise an antibody covalently attached to a nanoparticle;

    detecting an unbound particle signal transmitted from within the lumen of subsurface vasculature, wherein the unbound particle signal is indicative of functionalized particles that are not interacting with the one or more target analytes;

    detecting a background signal;

    applying a modulation to a portion of the subsurface vasculature, wherein the modulation alters the analyte response signal and the unbound particle signal, such that the analyte response signal is affected differently than the unbound particle signal and the background signal; and

    differentiating the analyte response signal from the unbound particle signal and the background signal based, at least in part, on the modulation.

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