Fluid extraction and drug delivery system and methods using microneedles
First Claim
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1. A device for sampling fluid, comprising:
- a first member having an array of microneedles and, coplanar therewith, an array of optical detectors, optical detectors of said array of optical detectors being adapted to detect hemoglobin in the body of a human or animal subject;
a controller configured to receive signals from the detectors and to calculate a position for insertion of a selected one of the microneedle responsively to the detector signals, the controller being configured to calculate said position either by itself or by conveying data to a remote computation device;
a drive motor arranged to move the first member to position the selected one of the microneedles responsively to said position for insertion;
a mechanism constructed to translate the selected one of the microneedles along an axis thereof such that the selected one of microneedles can be inserted in a human or animal subject.
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Abstract
Devices systems and methods for fluid extraction and delivery to human or animal hosts are described. In embodiments, microneedles are employed to provide low infection risk and painless access to and administration of fluids. The disclosed embodiments address, among others, issues of cost, portability, ease of use in remote settings including use by untrained personnel, and others.
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Citations
23 Claims
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1. A device for sampling fluid, comprising:
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a first member having an array of microneedles and, coplanar therewith, an array of optical detectors, optical detectors of said array of optical detectors being adapted to detect hemoglobin in the body of a human or animal subject; a controller configured to receive signals from the detectors and to calculate a position for insertion of a selected one of the microneedle responsively to the detector signals, the controller being configured to calculate said position either by itself or by conveying data to a remote computation device; a drive motor arranged to move the first member to position the selected one of the microneedles responsively to said position for insertion; a mechanism constructed to translate the selected one of the microneedles along an axis thereof such that the selected one of microneedles can be inserted in a human or animal subject. - View Dependent Claims (2, 3, 4, 5, 6, 7)
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8. A system for extracting blood from a vein of a subject, the system comprising:
- one or more microneedles;
an array of photodetectors to determine the location of the vein for the extraction of blood; a motor operatively connected to the one or more microneedles to move the micro-needles; and a controller configured to process a signal from the array of photodetectors and to operate the motor to move a selected microneedle of the one or more microneedles to the location of the vein for the extraction of blood; a housing for mounting the one or more microneedles, the motor, the array of photodetectors, and the controller; wherein the housing is constructed to be placed on the skin of the subject such that the one or more microneedles and the photodetector array face the skin but do not contact the skin; the system further comprising an actuator for pushing the selected microneedle into the vein; wherein the controller is configured to operate the actuator to push the selected microneedle into the vein after the selected microneedle is moved to the location of the vein. - View Dependent Claims (9, 10, 11, 12, 13, 14, 15, 16)
- one or more microneedles;
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17. A device for sampling fluid, comprising:
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a first member having an array of microneedles and an array of optical detectors, optical detectors of said array of optical detectors being constructed to detect hemoglobin in the body of a human or animal subject; a controller configured to receive signals from the detectors and to calculate a position for insertion of a selected one of the microneedle responsively to the detector signals, the controller being configured to calculate said position either by itself or by receiving said position from a remote computation device; a drive motor arranged to move the first member to position the selected one of the microneedles responsively to said position for insertion; a mechanism for translating the selected one of the microneedles along an axis thereof such that the selected one of microneedles can be inserted in a human or animal subject. - View Dependent Claims (18, 19, 20, 21, 22, 23)
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Specification