Surface coatings

• US 10,543,299 B2
• Filed: 10/03/2017
• Issued: 01/28/2020
• Est. Priority Date: 10/03/2016
• Status: Active Grant

• Current Assignee: Microvention Incorporated (Terumo Corporation)
• Original Assignee: Microvention Incorporated (Terumo Corporation)
• Inventors: Baldwin, Aaron, Belletto, John, Beuthin, Wendy
• Primary Examiner(s): Sasan, Aradhana
• Application Number:
  US15/724,135
• Publication Number:
  US 20180093019A1
• Time in Patent Office: 847 Days
• Field of Search: None
• CPC Class Codes: A61F 2/82 Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents stent-grafts for tubular structures of the body other than blood vessels A61F2/04; stent-grafts for blood vessels A61F2/07; instruments specially adapted for placement or removal of stents or stent-grafts A61F2/95; for closing wounds, or holding wounds closed A61B17/04 - A61B17/115; dilators A61M29/00
• CPC Class Codes: A61F 2/885 comprising a coil including a plurality of spiral or helical sections with alternate directions around a central axis
• CPC Class Codes: A61F 2/91 made from perforated sheet material or tubes, e.g. perforated by laser cuts or etched holes
• CPC Class Codes: A61F 2210/0076 multilayered, e.g. laminated structures
• CPC Class Codes: A61F 2230/0019 rectangular
• CPC Class Codes: A61F 2240/001 Designing or manufacturing processes
• CPC Class Codes: A61F 2250/0067 Means for introducing or releasing pharmaceutical products into the body
• CPC Class Codes: A61L 2300/42 Anti-thrombotic agents, anticoagulants, anti-platelet agents
• CPC Class Codes: A61L 2400/18 Modification of implant surfaces in order to improve biocompatibility, cell growth, fixation of biomolecules, e.g. plasma treatment
• CPC Class Codes: A61L 2420/02 Methods for coating medical devices
• CPC Class Codes: A61L 31/06 obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds A61L31/041 takes precedence
• CPC Class Codes: A61L 31/10 Macromolecular materials
• CPC Class Codes: A61L 31/16 Biologically active materials, e.g. therapeutic substances A61L31/047 takes precedence

Abstract

Described herein are substrate coatings.

Claims

1. A method of functionalizing a surface of an implantable medical device, the method including:

depositing a dopamine or dopamine-like compound on the surface to form a functionalized surface; and

depositing phosphorylethanolamine on the functionalized surface.

2. The method of claim 1, further comprising depositing a diamine, multifunctional amine, or multifunctional amine polymer on the functionalized surface.

3. The method of claim 1, further comprising conjugating a phosphate containing compound onto the functionalized surface.

4. The method of claim 3, wherein the phosphate containing compound is phosphorylcholine.

5. The method of claim 1, wherein the dopamine or dopamine-like compound is

6. A method of functionalizing a surface of an implantable medical device, the method including:

depositing a dopamine or dopamine-like compound on the surface to form a functionalized surface; and

depositing taurine on the functionalized surface.

7. The method of claim 6, further comprising depositing a diamine, multifunctional amine, or multifunctional amine polymer on the functionalized surface.

8. The method of claim 6, further comprising conjugating a phosphate containing compound onto the functionalized surface.

9. The method of claim 8, wherein the phosphate containing compound is phosphorylcholine.

10. The method of claim 6, wherein the dopamine or dopamine-like compound is

11. A method of functionalizing a surface of an implantable medical device, the method including:

depositing a dopamine or dopamine-like compound on the surface to form a functionalized surface; and

depositing a primary amine zwitterion on the functionalized surface.

12. The method of claim 11, further comprising depositing a diamine, multifunctional amine, or multifunctional amine polymer on the functionalized surface.

13. The method of claim 11, further comprising conjugating a phosphate containing compound onto the functionalized surface.

14. The method of claim 13, wherein the phosphate containing compound is phosphorylcholine.

15. The method of claim 11, wherein the dopamine or dopamine-like compound is