Thermosensitive nanocapsules and preparing method thereof
First Claim
1. A method for preparing thermosensitive nanocapsules, wherein the thermosensitive nanocapsules are prepared by forming a wall material from a free radical polymerization of two different N-alkyl acrylamide monomers;
- the method comprises the following steps;
(1) making an emulsifier aqueous solution by mixing an emulsifier and deionized water to form a water phase;
(2) mixing and fully stirring a core material, the two different N-alkyl acrylamide monomers, a crosslinking agent, an initiator and a co-stabilizer to form an oil phase;
(3) adding the water phase to the oil phase, forming microemulsion by shearing, and then forming a nanoemulsion via sonication; and
(4) introducing nitrogen into the nanoemulsion and carrying out a reaction at 40-80°
C., finally obtaining the thermosensitive nanocapsules;
wherein the two N-alkyl acrylamide have a general formula of
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Abstract
The present invention discloses a thermosensitive nanocapsule and a preparing method thereof. The thermosensitive nanocapsule includes core materials and wall materials. The preparing method includes: first, making water phase and oil phase respectively, forming microemulsion by means of high speed shearing after mixing, and forming nanoemulsion via ultrasonic treatment or high pressure homogenization; then adding nitrogen to the emulsion and carrying out the reaction under a temperature of 40-80° C. for 3-4 hrs in the nitrogen atmosphere; finally obtaining the thermosensitive nanocapsule with an embedding rate of 90-94%, a particle size of less than 150 nm and a dimension polydispersity index of 0.09-0.17. In present invention, the monomer that forms the wall material of the nanocapsules is made from common biological materials, and has a good biocompatibility. The wall material has a temperature sensitivity, and can control the delayed release of core material by adjusting temperature.
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Citations
16 Claims
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1. A method for preparing thermosensitive nanocapsules, wherein the thermosensitive nanocapsules are prepared by forming a wall material from a free radical polymerization of two different N-alkyl acrylamide monomers;
- the method comprises the following steps;
(1) making an emulsifier aqueous solution by mixing an emulsifier and deionized water to form a water phase; (2) mixing and fully stirring a core material, the two different N-alkyl acrylamide monomers, a crosslinking agent, an initiator and a co-stabilizer to form an oil phase; (3) adding the water phase to the oil phase, forming microemulsion by shearing, and then forming a nanoemulsion via sonication; and (4) introducing nitrogen into the nanoemulsion and carrying out a reaction at 40-80°
C., finally obtaining the thermosensitive nanocapsules;wherein the two N-alkyl acrylamide have a general formula of - View Dependent Claims (2, 3, 4, 5, 6, 8, 9, 10, 11, 12, 13, 14, 15, 16)
- the method comprises the following steps;
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7. A method for preparing thermosensitive nanocapsules, wherein the thermosensitive nanocapsules are prepared by forming a wall material from a free radical polymerization of two different N-alkyl acrylamide monomers;
- the method comprises the following steps;
(1) making an emulsifier aqueous solution by mixing an emulsifier and deionized water to form a water phase; (2) mixing and fully stirring a core material, the two different N-alkyl acrylamide monomers, a crosslinking agent, an initiator and a co-stabilizer to form an oil phase; (3) adding the water phase to the oil phase, forming microemulsion by shearing, and then forming a nanoemulsion via sonication; and (4) introducing nitrogen into the nanoemulsion and carrying out a reaction at 40-80°
C., finally obtaining the thermosensitive nanocapsules;wherein the two N-alkyl acrylamide have a general formula of
- the method comprises the following steps;
Specification