Slip chip device and methods

• US 10,543,485 B2
• Filed: 05/25/2016
• Issued: 01/28/2020
• Est. Priority Date: 03/24/2009
• Status: Active Grant

• Current Assignee: University of Chicago
• Original Assignee: University of Chicago
• Inventors: Ismagilov, Rustem F., Du, Wenbin, Li, Liang, Shen, Feng, Nichols, Kevin Paul Flood, Chen, Delai, Kreutz, Jason Eugene
• Primary Examiner(s): Hurst, Jonathan M
• Application Number:
  US15/164,788
• Publication Number:
  US 20160256870A1
• Time in Patent Office: 1,343 Days
• CPC Class Codes: B01F 33/304 the mixing being performed in a mixing chamber where the products are brought into contact
• CPC Class Codes: B01L 2200/025 Align devices or objects to ensure defined positions relative to each other
• CPC Class Codes: B01L 2200/027 for microfluidic devices
• CPC Class Codes: B01L 2300/0609 Holders integrated in container to position an object
• CPC Class Codes: B01L 2300/0809 rectangular shaped
• CPC Class Codes: B01L 2300/0816 Cards, e.g. flat sample carriers usually with flow in two horizontal directions
• CPC Class Codes: B01L 2300/0861 Configuration of multiple channels and/or chambers in a single devices
• CPC Class Codes: B01L 2300/0864 comprising only one inlet and multiple receiving wells, e.g. for separation, splitting
• CPC Class Codes: B01L 2300/0867 Multiple inlets and one sample wells, e.g. mixing, dilution
• CPC Class Codes: B01L 2300/0887 Laminated structure
• CPC Class Codes: B01L 2300/0893 having a very large number of wells, microfabricated wells
• CPC Class Codes: B01L 2300/12 Specific details about materials
• CPC Class Codes: B01L 2300/168 Specific optical properties, e.g. reflective coatings
• CPC Class Codes: B01L 2400/065 sliding valves
• CPC Class Codes: B01L 3/5025 for parallel transport of multiple samples
• CPC Class Codes: B01L 3/502715 characterised by interfacing components, e.g. fluidic, electrical, optical or mechanical interfaces
• CPC Class Codes: B01L 3/502738 characterised by integrated valves microvalves F16K99/0001
• CPC Class Codes: B01L 3/502761 specially adapted for handling suspended solids or molecules independently from the bulk fluid flow, e.g. for trapping or sorting beads, for physically stretching molecules investigating characteristics of particles G01N15/00
• CPC Class Codes: B01L 7/52 with provision for submitting samples to a predetermined sequence of different temperatures, e.g. for treating nucleic acid samples amplification or hybridisation processes per se C12Q1/68; controlling sequential reactions for synthesis B01J19/0046
• CPC Class Codes: C12Q 1/025 for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics antimicrobial activity C12Q1/18
• CPC Class Codes: C12Q 1/703 : Viruses associated with AIDS
• CPC Class Codes: G01N 21/78 : producing a change of colour
• CPC Class Codes: G01N 33/54386 : Analytical elements
• CPC Class Codes: H01L 2924/00 : Indexing scheme for arrangements or methods for connecting or disconnecting semiconductor or solid-state bodies as covered by H01L24/00
• CPC Class Codes: H01L 2924/0002 : Not covered by any one of groups H01L24/00, H01L24/00 and H01L2224/00

Abstract

A device is described having a first surface having a plurality of first areas and a second surface having a plurality of second areas. The first surface and the second surface are opposed to one another and can move relative to each other from at least a first position where none of the plurality of first areas, having a first substance, are exposed to plurality of second areas, having a second substance, to a second position. When in the second position, the plurality of first and second areas, and therefore the first and second substances, are exposed to one another. The device may further include a series of ducts in communication with a plurality of first second areas to allow for a substance to be disposed in, or upon, the plurality of second areas when in the first position.

Claims

1. A reaction system for carrying out a reaction, the reaction system comprising:

a first part having a first surface;

a plurality of first areas located along a portion of the first surface; and

a second part having a second surface opposed to the first surface;

a plurality of second areas located along a portion of the second surface;

wherein at least one of the first surface of the first part and the second surface of the second part is configured to move relative to the other between a first position, wherein at least some of said plurality of first areas are exposed to at least some of said plurality of second areas so as to form a plurality of rows, each row comprising overlapping first areas and second areas in fluidic communication along said row;

a second position, wherein at least some of said plurality of first areas are exposed to at least some of said plurality of second areas so as to form a plurality of columns, each column comprising overlapping first areas and second areas in fluidic communication along said column;

wherein the first part and the second part are engaged with each other before and after the relative motion; and

wherein the first and second areas are configured to maintain at least one substance.

2. The reaction system of claim 1, further comprising a plurality of channels in said first or second part, wherein said plurality of channels are in fluidic communication with said plurality of rows of overlapping first and second areas in said first position.

3. The reaction system of claim 2, wherein said plurality of channels comprise inlet ducts or outlet ducts.

4. The reaction system of claim 1, further comprising a plurality of channels in said first or second part, wherein said plurality of channels are in fluidic communication with said plurality of columns of overlapping first and second areas in said second position.

5. The reaction system of claim 4, wherein said plurality of channels comprise inlet ducts or outlet ducts.

6. The reaction system of claim 1, wherein said relative motion is linear, rotational, or a combination of both.

7. The reaction system of claim 1, wherein said plurality of first areas are arranged in said first surface along rows extending parallel to one another.

8. The reaction system of claim 1, wherein said plurality of second areas are arranged in said second surface along rows extending parallel to one another.

9. The reaction system of claim 1, wherein said plurality of first areas or said plurality of second areas comprise ducts.

10. The reaction system of claim 1, wherein at least one first area or second area comprises a capture element.

11. The reaction system of claim 10, wherein the capture element is selected from the group consisting of antibodies, affinity-proteins, aptamers, beads, particles and biological cells.

12. The reaction system of claim 11, wherein the capture element is surface-bound antibodies or bead-bound antibodies.

13. The reaction system of claim 1, wherein the reaction comprises a synthetic reaction, a neutralization reaction, a decomposition reaction, a displacement reaction, a reduction-oxidation reaction, a precipitation, a crystallization, a combustion reaction, or a polymerization reaction.

14. The reaction system of claim 1, wherein the reaction produces or consumes a gaseous product.