PDGF and VEGF aptamers having improved stability and their use in treating PDGF and VEGF mediated diseases and disorders
First Claim
Patent Images
1. A nucleic acid molecule comprising the nucleic sequence
5′
- -C-C-G-Z-Z-C-A-A-G-Z-G-C-Z-Z-G-Z-A-G-G-A-Z-Z-Z-A-A-A-Z-G-G-3′
(SEQ ID NO;
831),wherein Z is a C-5 modified pyrimidine, and at least one of positions 24, 25 and 26 of the nucleic acid molecule comprise a phosphorothioate linkage or moiety, and wherein position 1 is the first nucleoside starting from the 5′
-terminus of the nucleic acid molecule.
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Abstract
Aptamers having improved stability against nucleases that bind PDGF and aptamers that bind VEGF are provided. In addition, aptamer constructs comprising a PDGF aptamer and a VEGF aptamer are provided. Pharmaceutical compositions comprising the aptamers and aptamer constructs are provided, as well as methods of treating conditions using the aptamers and aptamer constructs.
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Citations
8 Claims
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1. A nucleic acid molecule comprising the nucleic sequence
5′- -C-C-G-Z-Z-C-A-A-G-Z-G-C-Z-Z-G-Z-A-G-G-A-Z-Z-Z-A-A-A-Z-G-G-3′
(SEQ ID NO;
831),wherein Z is a C-5 modified pyrimidine, and at least one of positions 24, 25 and 26 of the nucleic acid molecule comprise a phosphorothioate linkage or moiety, and wherein position 1 is the first nucleoside starting from the 5′
-terminus of the nucleic acid molecule. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8)
- -C-C-G-Z-Z-C-A-A-G-Z-G-C-Z-Z-G-Z-A-G-G-A-Z-Z-Z-A-A-A-Z-G-G-3′
Specification