×

PDGF and VEGF aptamers having improved stability and their use in treating PDGF and VEGF mediated diseases and disorders

  • US 10,544,419 B2
  • Filed: 05/10/2018
  • Issued: 01/28/2020
  • Est. Priority Date: 09/09/2013
  • Status: Active Grant
First Claim
Patent Images

1. A nucleic acid molecule comprising the nucleic sequence
5′

  • -C-C-G-Z-Z-C-A-A-G-Z-G-C-Z-Z-G-Z-A-G-G-A-Z-Z-Z-A-A-A-Z-G-G-3′





    (SEQ ID NO;

         831),wherein Z is a C-5 modified pyrimidine, and at least one of positions 24, 25 and 26 of the nucleic acid molecule comprise a phosphorothioate linkage or moiety, and wherein position 1 is the first nucleoside starting from the 5′

    -terminus of the nucleic acid molecule.

View all claims
  • 2 Assignments
Timeline View
Assignment View
    ×
    ×