Methods and systems for diagnosing eye conditions, including macular degeneration

• US 10,545,341 B2
• Filed: 09/19/2016
• Issued: 01/28/2020
• Est. Priority Date: 03/16/2015
• Status: Active Grant

• Current Assignee: Magic Leap, Inc.
• Original Assignee: Magic Leap, Inc.
• Inventors: Samec, Nicole Elizabeth, Macnamara, John Graham, Harrises, Christopher M., Schowengerdt, Brian T., Abovitz, Rony, Baerenrodt, Mark
• Primary Examiner(s): Zhai, Kyle
• Application Number:
  US15/269,652
• Publication Number:
  US 20170007111A1
• Time in Patent Office: 1,226 Days
• Field of Search: None
• CPC Class Codes: A61B 2562/0204 Acoustic sensors
• CPC Class Codes: A61B 2562/0219 Inertial sensors, e.g. accelerometers, gyroscopes, tilt switches
• CPC Class Codes: A61B 2562/0247 Pressure sensors
• CPC Class Codes: A61B 3/0008 provided with illuminating means A61B3/117 takes precedence; goniolenses used for laser treatment A61F9/009; illuminating means for optical instruments G02B27/00
• CPC Class Codes: A61B 3/0025 characterised by electronic signal processing, e.g. eye models
• CPC Class Codes: A61B 3/005 Constructional features of the display
• CPC Class Codes: A61B 3/022 for testing contrast sensitivity
• CPC Class Codes: A61B 3/024 for determining the visual field, e.g. perimeter types
• CPC Class Codes: A61B 3/028 for testing visual acuity; for determination of refraction, e.g. phoropters
• CPC Class Codes: A61B 3/0285 Phoropters
• CPC Class Codes: A61B 3/032 Devices for presenting test symbols or characters, e.g. test chart projectors A61B3/036 takes precedence
• CPC Class Codes: A61B 3/036 for testing astigmatism
• CPC Class Codes: A61B 3/063 for testing light sensitivity, i.e. adaptation
• CPC Class Codes: A61B 3/066 for testing colour vision
• CPC Class Codes: A61B 3/08 for testing binocular or stereoscopic vision, e.g. strabismus
• CPC Class Codes: A61B 3/085 for testing strabismus
• CPC Class Codes: A61B 3/10 Objective types, i.e. instruments for examining the eyes independent of the patients' perceptions or reactions
• CPC Class Codes: A61B 3/1005 for measuring distances inside the eye, e.g. thickness of the cornea A61B3/11 takes precedence
• CPC Class Codes: A61B 3/101 for examining the tear film
• CPC Class Codes: A61B 3/1015 for wavefront analysis
• CPC Class Codes: A61B 3/102 : for optical coherence tomography [OCT]
• CPC Class Codes: A61B 3/1035 : for measuring astigmatism testing astigmatism A61B3/036
• CPC Class Codes: A61B 3/113 : for determining or recording eye movement
• CPC Class Codes: A61B 3/12 : for looking at the eye fundus, e.g. ophthalmoscopes A61B3/13 takes precedence
• CPC Class Codes: A61B 3/1216 : for diagnostics of the iris
• CPC Class Codes: A61B 3/1241 : specially adapted for observation of ocular blood flow, e.g. by fluorescein angiography
• CPC Class Codes: A61B 3/13 : Ophthalmic microscopes
• CPC Class Codes: A61B 3/14 : Arrangements specially adapted for eye photography apparatus or arrangements for taking photographs per se G03B
• CPC Class Codes: A61B 3/165 : Non-contacting tonometers
• CPC Class Codes: A61B 5/0059 : using light, e.g. diagnosis by transillumination, diascopy, fluorescence A61B5/0093, A61B5/1455, A61B5/02416 and A61B5/0261 take precedence
• CPC Class Codes: A61B 5/0066 : Optical coherence imaging
• CPC Class Codes: A61B 5/0077 : Devices for viewing the surface of the body, e.g. camera, magnifying lens
• CPC Class Codes: A61B 5/01 : Measuring temperature of body parts ; Diagnostic temperature sensing, e.g. for malignant or inflamed tissue clinical contact thermometers G01K13/20
• CPC Class Codes: A61B 5/12 : Audiometering
• CPC Class Codes: A61B 5/14532 : for measuring glucose, e.g. by tissue impedance measurement
• CPC Class Codes: A61B 5/1455 : using optical sensors, e.g. spectral photometrical oximeters
• CPC Class Codes: A61B 5/14555 : specially adapted for the eye fundus
• CPC Class Codes: A61B 5/361 : Detecting fibrillation
• CPC Class Codes: A61B 5/369 : Electroencephalography [EEG] devices for psychotechnics A61B5/16
• CPC Class Codes: A61B 5/398 : Electrooculography [EOG], e.g. detecting nystagmus; Electroretinography [ERG]
• CPC Class Codes: A61B 5/6803 : Head-worn items, e.g. helmets, masks, headphones or goggles
• CPC Class Codes: A61B 8/10 : Eye inspection
• CPC Class Codes: A61B 8/461 : Displaying means of special interest
• CPC Class Codes: A61F 2007/0004 : Eyes or part of the face surrounding the eyes
• CPC Class Codes: A61F 2007/004 : Hip
• CPC Class Codes: A61F 2009/00863 : Retina
• CPC Class Codes: A61F 9/0026 : Ophthalmic product dispenser attachments to facilitate positioning near the eye
• CPC Class Codes: A61H 2201/165 : Wearable interfaces
• CPC Class Codes: A61M 2021/0022 : by the tactile sense, e.g. vibrations
• CPC Class Codes: A61M 2021/0027 : by the hearing sense
• CPC Class Codes: A61M 2021/0066 : with heating or cooling
• CPC Class Codes: A61M 21/02 : for inducing sleep or relaxation, e.g. by direct nerve stimulation, hypnosis, analgesia for massage A61H; electrotherapy A61N, e.g. applying alternating or intermittent electric currents for producing anaesthesia A61N1/36021
• CPC Class Codes: A61M 2205/3375 : Acoustical, e.g. ultrasonic, measuring means
• CPC Class Codes: A61M 2205/507 : Head Mounted Displays [HMD]
• CPC Class Codes: A61N 2005/0648 : the light being directed to the eyes
• CPC Class Codes: G02B 2027/0138 : comprising image capture systems, e.g. camera
• CPC Class Codes: G02B 2027/014 : comprising information/image processing systems
• CPC Class Codes: G02B 2027/0185 : Displaying image at variable distance
• CPC Class Codes: G02B 21/0032 : Optical details of illumination, e.g. light-sources, pinholes, beam splitters, slits, fibers G02B21/0036 - G02B21/008; means for illumination of specimens in general G02B21/06
• CPC Class Codes: G02B 27/0093 : with means for monitoring data relating to the user, e.g. head-tracking, eye-tracking
• CPC Class Codes: G02B 27/0172 : characterised by optical features
• CPC Class Codes: G02B 27/0179 : Display position adjusting means not related to the information to be displayed
• CPC Class Codes: G02C 7/027 : considering wearer's parameters
• CPC Class Codes: G06T 19/006 : Mixed reality object pose determination, tracking or camera calibration for mixed reality G06T7/00
• CPC Class Codes: G06T 2207/10024 : Color image
• CPC Class Codes: G06T 2207/10148 : Varying focus
• CPC Class Codes: G06T 2207/10152 : Varying illumination
• CPC Class Codes: G06T 2207/30041 : Eye; Retina; Ophthalmic
• CPC Class Codes: G16H 20/17 : delivered via infusion or injection
• CPC Class Codes: G16H 40/63 : for local operation
• CPC Class Codes: G16H 40/67 : for remote operation
• CPC Class Codes: G16H 50/20 : for computer-aided diagnosis, e.g. based on medical expert systems

Abstract

Configurations are disclosed for a health system to be used in various healthcare applications, e.g., for patient diagnostics, monitoring, and/or therapy. The health system may comprise a light generation module to transmit light or an image to a user, one or more sensors to detect a physiological parameter of the user'"'"'s body, including their eyes, and processing circuitry to analyze an input received in response to the presented images to determine one or more health conditions or defects.

Claims

1. A wearable augmented reality display device comprising:

a light source configured to output light for propagation into an eye of a wearer of the wearable augmented reality display device to form an image in the eye; and

a stack of waveguides configured to pass light from the world into the eye of the wearer, wherein each of the waveguides is configured to in-couple light from the light source and present augmented reality content to the wearer, the augmented reality content comprising a user interface configured to receive input from the wearer, wherein each waveguide of the one or more waveguides is configured to guide the in-coupled light therein by total internal reflection between opposing surfaces of the waveguide, and wherein one or more waveguides of the stack of waveguides are configured to output the light to the eye with a different amount of wavefront divergence than one or more other waveguides of the stack of waveguides,

wherein the wearable augmented reality device is configured to project the image to a particular portion of the wearer'"'"'s eye and to detect a response regarding the image to determine the health of that portion of the eye.

2. The device of claim 1, wherein the wearable augmented reality device is configured to project the image to another portion of the wearer'"'"'s eye and to detect a response regarding the image to determine the health of that portion of the eye.

3. The device of claim 2, wherein the wearable augmented reality device is configured to identify anomalies in the wearer'"'"'s eye based on the portions of the eye tested.

4. The device of claim 3, wherein the user interface is configured to receive a voluntary wearer input regarding the image projected to the wearer'"'"'s eye, wherein the voluntary wearer input is the response regarding the image.

5. The device of claim 3, wherein the ophthalmic system comprises a camera configured to image the eye, wherein the ophthalmic system is configured to detect an involuntary wearer response regarding the image by imaging the eye with the camera.

6. The device of claim 5, wherein the involuntary wearer response regarding the image is a change in gaze.

7. The device of claim 3, wherein the anomalies comprise a location of macular degeneration.

8. The device of claim 7, wherein the ophthalmic system comprises a camera configured to image the eye, wherein the ophthalmic system is configured to determine a location of macular degeneration based imaging of a retina of the eye.

9. The device of claim 1, wherein the wearable augmented reality device is configured to:

project a first image and a second image to a same portion of the wearer'"'"'s eye;

detect a response regarding each image; and

compare the first response to the second response to determine the health of that portion of the eye.

10. The device of claim 9, wherein at least one hue present in the first image is different from at least one hue present in the second image.

11. The device of claim 10, wherein the wearable augmented reality device is configured to identify areas of reduced color sensitivity based on the portions of the eye tested.

12. The device of claim 1, the wearable augmented reality device is configured to determine the health of a portion of the eye in real time.

13. The device of claim 1, wherein the wearable augmented reality device is configured to store data regarding the projected images and the detected responses, and wherein the determining the health of a portion of the eye is performed at a later time based on the stored data.

14. The device of claim 13, wherein the wearable augmented reality device is further configured to transmit the stored data to a remote location, and wherein the determining the health of a portion of the eye is performed remotely based on the transmitted data.

15. The device of claim 1, wherein the display platform comprises a fiber scanning display.

16. The device of claim 1, wherein the wearable augmented reality display device is configured to produce images, via the stack of waveguides, with multiple wavefront divergence corresponding to multiple depth planes.

17. The device of claim 16, wherein the multiple depth planes comprises at least 2 depth planes.

18. The device of claim 17, wherein the wearable device is configured to increase or decrease a spatial frequency of a periodic image projected to damaged areas of the eye.

19. The device of claim 1, wherein the wearable augmented reality device is configured to project the image to a particular portion of the wearer'"'"'s eye and to detect, via the user interface, a response regarding the image to determine the health of that portion of the eye.

20. The device of claim 1, wherein each waveguide of the stack of waveguides comprises a diffractive in-coupling optical element.

21. The device of claim 1, wherein each waveguide of the stack of waveguides comprises a diffractive out-coupling optical element configured to output the in-coupled light from the waveguide.