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Compositions and methods for preventing and treating heterotopic ossification and pathologic calcification

  • US 10,548,908 B2
  • Filed: 09/13/2017
  • Issued: 02/04/2020
  • Est. Priority Date: 09/15/2016
  • Status: Active Grant
First Claim
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1. A method for inhibiting osteogenesis in mesenchymal stem cells, comprising contacting said mesenchymal stem cells with:

  • a) a combination of a Hedgehog (Hh) pathway antagonist together with;

    i) vitamin D, cholecalciferol or a vitamin D analog;

    orii) a statin;

    orb) a combination of;

    i) an Hh pathway antagonist;

    ii) vitamin D, cholecalciferol or a vitamin D analog; and

    iii) a statin;

    wherein the compounds of paragraphs a) and b) are administered to cells in a co-timely manner, and wherein the dosage of each compound is sufficient to make the combination effective at inhibiting osteogenesis.

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