Three dimensional multislab, multi-shot magnetic resonance elastography

• US 10,551,464 B2
• Filed: 08/07/2014
• Issued: 02/04/2020
• Est. Priority Date: 10/31/2013
• Status: Active Grant

• Current Assignee: Board of Trustees of The University of Illinois
• Original Assignee: Board of Trustees of The University of Illinois
• Inventors: Johnson, Curtis L., Sutton, Bradley, Georgiadis, John G., Holtrop, Joseph L.
• Primary Examiner(s): Patel, Paresh
• Application Number:
  US15/032,202
• Publication Number:
  US 20160266225A1
• Time in Patent Office: 2,007 Days
• Field of Search: None
• CPC Class Codes: G01R 33/5611 Parallel magnetic resonance imaging, e.g. sensitivity encoding [SENSE], simultaneous acquisition of spatial harmonics [SMASH], unaliasing by Fourier encoding of the overlaps using the temporal dimension [UNFOLD], k-t-broad-use linear acquisition speed-up technique [k-t-BLAST], k-t-SENSE structural details of arrays of sub-coils G01R33/3415
• CPC Class Codes: G01R 33/56358 Elastography
• CPC Class Codes: G01R 33/56545 caused by finite or discrete sampling, e.g. Gibbs ringing, truncation artefacts, phase aliasing artefacts
• CPC Class Codes: G01R 33/5676 Gating or triggering based on an MR signal, e.g. involving one or more navigator echoes for motion monitoring and correction

Abstract

A method and system provides an acquisition scheme for generating MRE displacement data with whole-sample coverage, high spatial resolution, and adequate SNR in a short scan time. The method and system can acquire in-plane k-space shots over a volume of a sample divided into a plurality of slabs that each include a plurality of slices to obtain three dimensional multislab, multishot data, can apply refocusing pulses to the sample, can acquire navigators after the refocusing pulses, and can correct for phase errors based on an averaging of the navigators.

Claims

1. A method of magnetic resonance elastography, the method comprising:

applying, by a system including a processor, a first refocusing pulse to a sample, wherein the sample is divided into a plurality of slabs that each include a plurality of slices;

applying, by the system, first and second motion encoding gradients to the sample, wherein the first motion encoding gradient is applied before the first refocusing pulse, and wherein the second motion encoding gradient is applied after the first refocusing pulse;

providing, by the system, a plurality of gradient blips to define a plurality of sample planes of one of the plurality of slabs;

acquiring, by the system, a k-space shot after the second motion encoding gradient is applied, wherein the k-space shot is acquired according to a stack of in-plane samples separated according to the plurality of gradient blips to obtain a three-dimensional k-space sample of one of the plurality of slabs; and

repeating, by the system, the applying of the first refocusing pulse, the applying of the first and second motion encoding gradients and the acquiring of the k-space shot over the plurality of slabs to obtain three dimensional multislab, multishot data.

2. The method of claim 1, further comprising generating, by the system, a modulus map image for the sample according to the three dimensional multislab, multishot data.

3. The method of claim 1, further comprising:

determining, by the system, a tissue relaxation time for the sample; and

calculating, by the system, a repetition time according to the tissue relaxation time, wherein obtaining of the three dimensional multislab, multishot data is according to the repetition time.

4. The method of claim 1, further comprising:

applying, by the system, a second refocusing pulse to the sample after the k-space shot is acquired;

acquiring, by the system, a three-dimensional navigator after the second refocusing pulse is applied, wherein the three-dimensional navigator is acquired as a single-shot stack of spirals; and

performing, by the system, a correction for phase errors, the correction being performed based on the three-dimensional navigator.

5. The method of claim 4, wherein the acquiring of the three-dimensional navigator is repeated over the plurality of slabs of the sample to acquire a plurality of three-dimensional navigators, wherein the correction for the phase errors is performed based on the plurality of three-dimensional navigators.

6. The method of claim 5, further comprising:

averaging, by the system, the plurality of three-dimensional navigators, wherein the correction for the phase errors is performed based on the averaging of the plurality of three-dimensional navigators.

7. The method of claim 1, wherein a total number of excitations is equal to a number of acquired k-space shots times a number of slices per slab, and wherein the first and second motion encoding gradients are flow-compensated.

8. The method of claim 1, wherein obtaining of the three dimensional multislab, multishot data includes utilizing parallel imaging of the sample.

9. The method of claim 1, wherein adjacent slabs of the plurality of slabs are overlapped, and wherein data acquired for at least a portion of overlapped slices is discarded.

10. The method of claim 1, wherein the sample is an in vivo brain, wherein adjacent slabs of the plurality of slabs are overlapped by at least 25 percent, and wherein data acquired for at least a portion of overlapped slices is discarded.

11. A system comprising:

an actuator for applying a vibration to a sample;

a magnetic resonance system for facilitating applying magnetic resonance elastography to the sample;

a processing system including a processor coupled with the actuator and the magnetic resonance system; and

a memory that stores executable instructions which, responsive to being executed by the processing system, facilitate performance of operations, the operations comprising;

providing a plurality of gradient blips to define a plurality of sample planes of one of a plurality of slabs;

acquiring a k-space shot over the plurality of sample planes of the one of the plurality of slabs, wherein the plurality of slabs define a volume of the sample, and wherein the one of the plurality of slabs includes a plurality of slices corresponding to the plurality of sample planes;

repeating the acquiring of the k-space shot for each of the plurality of slabs to obtain three dimensional multislab, multishot data;

applying refocusing pulses to the sample;

acquiring three-dimensional navigators after the refocusing pulses; and

correcting for phase errors based on an averaging of the three-dimensional navigators.

12. The system of claim 11, wherein the operations further comprise:

determining a tissue relaxation time for the sample; and

calculating a repetition time according to the tissue relaxation time, wherein obtaining of the three dimensional multislab, multishot data is according to the repetition time.

13. The system of claim 11, wherein the operations further comprise:

performing parallel imaging of the sample to facilitate obtaining of the three dimensional multislab, multishot data.

14. The system of claim 11, wherein a total number of excitations is equal to a number of acquired k-space shots times a number of slices per slab.

15. The system of claim 11, wherein the operations further comprise generating a modulus map image for the sample according to the three dimensional multislab, multishot data.

16. A machine-readable storage device comprising executable instructions which, responsive to being executed by a processing system including a processor, facilitate performance of operations, the operations comprising:

applying a first refocusing pulse to a sample that is divided into a plurality of slabs that each include a plurality of slices;

applying first and second motion encoding gradients to the sample, wherein the first motion encoding gradient is applied before the first refocusing pulse, and wherein the second motion encoding gradient is applied after the first refocusing pulse;

providing a plurality of gradient blips to define a plurality of sample planes of a slab of the plurality of slabs that define a volume of the sample;

acquiring a k-space shot over the plurality of sample planes after the second motion encoding gradient is applied; and

repeating the applying of the first refocusing pulse, the applying of the first and second motion encoding gradients and the acquiring of the k-space shot over the plurality of sample planes of each slab of the plurality of slabs of the sample to obtain three dimensional multislab, multishot data.

17. The machine-readable storage device of claim 16, wherein the operations further comprise:

determining a tissue relaxation time for the sample; and

calculating a repetition time according to the tissue relaxation time, wherein obtaining of the three dimensional multislab, multishot data is according to the repetition time.

18. The machine-readable storage device of claim 16, wherein the operations further comprise:

applying second refocusing pulses to the sample after the k-space shot is acquired;

acquiring three-dimensional navigators after each of the second refocusing pulses are applied;

averaging the three-dimensional navigators; and

correcting for phase errors based on the averaging of the three-dimensional navigators.

19. The machine-readable storage device of claim 16, wherein a total number of excitations is equal to a number of acquired k-space shots times a number of slices per slab.

20. The machine-readable storage device of claim 16, wherein obtaining of the three dimensional multislab, multishot data includes utilizing parallel imaging of the sample.