Apparatus and method for generating chemical signatures using differential desorption
First Claim
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1. A device comprising:
- a wand including a plastic ticket, where the plastic ticket is adapted to contact a sample at a plurality of target areas on the plastic ticket including a first target area of the plurality of target areas and a second target area of the plurality of target areas, where the first target area is a distance from the second target area;
a desorption ionization source adapted to generate a stream of energetic particles at a first temperature at the first target area to form a first plurality of sample ions, where the desorption ionization source is adapted to generate the stream of energetic particles at a substantially constant second temperature at the second target area to form a second plurality of sample ions; and
an analyzer, adapted to analyze one or both the first plurality of sample ions and the second plurality of sample ions.
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Abstract
The present invention is directed to a method and device to generate a chemical signature for a mixture of analytes. The present invention involves using a SPME surface to one or both absorb and adsorb the mixture of analytes. In an embodiment of the invention, the surface is then exposed to different temperature ionizing species chosen with appropriate spatial resolution to desorb a chemical signature for the mixture of analytes.
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Citations
20 Claims
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1. A device comprising:
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a wand including a plastic ticket, where the plastic ticket is adapted to contact a sample at a plurality of target areas on the plastic ticket including a first target area of the plurality of target areas and a second target area of the plurality of target areas, where the first target area is a distance from the second target area; a desorption ionization source adapted to generate a stream of energetic particles at a first temperature at the first target area to form a first plurality of sample ions, where the desorption ionization source is adapted to generate the stream of energetic particles at a substantially constant second temperature at the second target area to form a second plurality of sample ions; and an analyzer, adapted to analyze one or both the first plurality of sample ions and the second plurality of sample ions. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 14)
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9. A device comprising:
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a wand including a plastic ticket, where the plastic ticket is adapted to contact a sample at a first target area and a second target area on the plastic ticket, where the first target area is a separate region from the second target area; a mesh; a power supply adapted to supply an electric current to the mesh, where the mesh is in close proximity to one or both the first target area and the second target area; a desorption ionization source adapted to generate a stream of energetic particles at a first temperature at the first target area and at a second temperature at the second target area to form a plurality of sample ions, where the second target area has not been exposed to the stream of energetic particles at the first temperature; and an analyzer, adapted to analyze the plurality of sample ions. - View Dependent Claims (10, 11, 12, 13)
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15. A method of analyzing a sample comprising:
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contacting a wand comprising a plastic ticket with a sample, where the plastic ticket is of sufficient size to permit multiple exposure of the plastic ticket to a plurality of different temperature streams of energetic particles from a desorption ionization source; locating the plastic ticket in close proximity with a mesh; heating the mesh with an electric current from a power supply; directing a first stream of energetic particles at a first temperature from the plurality of different temperature streams of energetic particles at a first target area on the plastic ticket, where the first stream of energetic particles forms a plurality of first sample ions, where the second target area has not been exposed to the first stream of energetic particles at the first temperature; directing a second stream of energetic particles at a second temperature from the plurality of different temperature streams of energetic particles at a second target area on the plastic ticket, where the second area has not been exposed to the first stream of energetic particles at the first temperature, where the second stream of energetic particles forms a plurality of second sample ions; and analyzing one or both the plurality of first sample ions and the plurality of second sample ions, thereby analyzing the sample. - View Dependent Claims (16, 17, 18, 19, 20)
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Specification