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Method and device for improving prediction and detection of change in a physiological condition

  • US 10,555,677 B2
  • Filed: 08/23/2013
  • Issued: 02/11/2020
  • Est. Priority Date: 08/23/2013
  • Status: Active Grant
First Claim
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1. A device comprising one or more processors configured to:

  • obtain continuously over time, via one or more sensors, both a heart rhythm signal related to a heart rhythm of a subject and an interstitial fluid glucose level signal related to a glucose level of an interstitial fluid of the subject;

    analyze continuously over time changes in a pattern of a heart rate variability of the subject based on the heart rhythm signal;

    analyze continuously over time changes in the glucose level of the interstitial fluid based on the interstitial fluid glucose level signal;

    extract features from the pattern of the heart rate variability and the glucose level of the interstitial fluid;

    reduce the features extracted based on a ranking algorithm to eliminate certain features that do not signify a physiological event;

    combine the pattern of the heart rate variability and the interstitial fluid glucose level signal; and

    predict, for a physiological condition during a future time period of the subject for which the glucose level of the interstitial fluid is surrogate measurement, whether there would be a change in the physiological condition of the subject during the future time period, a prediction being based on the correlated changes in the pattern of the heart rate variability and the changes in the glucose level of the interstitial fluid, wherein a continuous glucose monitor is a surrogate measure for blood glucose measurement.

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