Compositions and methods for delivery of agents
First Claim
Patent Images
1. A method for delivering a therapeutic level of a protein of interest to a subject, the method comprising:
- administering to the subject at least two doses of lipid nanoparticles (LNPs) comprising an mRNA coding for the protein of interest, wherein the LNPs comprise an ionizable lipid, a helper lipid, a structural lipid, and a PEG-lipid,wherein the PEG-lipid is a compound of Formula (V—
OH);
1 Assignment
0 Petitions
Accused Products
Abstract
This disclosure provides improved lipid-based compositions, including lipid nanoparticle compositions, and methods of use thereof for delivering agents in vivo including nucleic acids and proteins. These compositions are not subject to accelerated blood clearance and they have an improved toxicity profile in vivo.
-
Citations
28 Claims
-
1. A method for delivering a therapeutic level of a protein of interest to a subject, the method comprising:
-
administering to the subject at least two doses of lipid nanoparticles (LNPs) comprising an mRNA coding for the protein of interest, wherein the LNPs comprise an ionizable lipid, a helper lipid, a structural lipid, and a PEG-lipid, wherein the PEG-lipid is a compound of Formula (V—
OH); - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28)
-
Specification