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Methods and devices for modulating cellular activity using ultrasound

  • US 10,556,132 B2
  • Filed: 06/24/2016
  • Issued: 02/11/2020
  • Est. Priority Date: 07/14/2008
  • Status: Active Grant
First Claim
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1. A method for modulating neuronal cellular activity of a neuronal cellular site in a subject, comprising:

  • (i) acoustically coupling at least one component for generating ultrasound waves to an external surface of the subject, and(ii) driving the at least one component for generating ultrasound waves to form at least one stimulus waveform at the neuronal cellular site, the stimulus waveform comprising a plurality of pulses, each pulse of the plurality comprising a plurality of acoustic cycles having a plurality of frequencies in a range from about 0.02 to about 100 MHz at the site of the cells to be modulated, wherein pulses of the plurality are repeated to produce spatial-peak temporal-average intensities of no more than 100 W/cm2 to modulate neuronal cellular activity at the neuronal cellular site.

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