Treatment of lung and pulmonary diseases and disorders
First Claim
1. A method of reducing vascular leak, edema, or inflammation in a lung of a patient having hyperoxia or acute lung injury comprising systemically administering to the patient an effective amount of umbilical cord tissue-derived cells, wherein the umbilical cord tissue-derived cells are isolated from human umbilical cord tissue substantially free of blood, are capable of self-renewal and expansion in culture, have the potential to differentiate into cells of at least a lung tissue, and do not express CD117, hTERT or telomerase, andwherein the levels of keratinocyte factor, gamma interferon-inducible cytokine, interleukin 1-alpha and monocyte chemotactic factor-1 are reduced in the lung of the patient having hyperoxia or acute lung injury.
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Abstract
Compositions and methods of using cells derived from umbilical cord tissue to stimulate and support lung tissue angiogenesis, to improve blood flow to lung tissue, to regenerate, repair, and improve lung tissue damaged by lung disease, disorder and/or injury, and to protect lung tissue from damage caused by lung disease, disorder and/or injury in a patient.
236 Citations
32 Claims
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1. A method of reducing vascular leak, edema, or inflammation in a lung of a patient having hyperoxia or acute lung injury comprising systemically administering to the patient an effective amount of umbilical cord tissue-derived cells, wherein the umbilical cord tissue-derived cells are isolated from human umbilical cord tissue substantially free of blood, are capable of self-renewal and expansion in culture, have the potential to differentiate into cells of at least a lung tissue, and do not express CD117, hTERT or telomerase, and
wherein the levels of keratinocyte factor, gamma interferon-inducible cytokine, interleukin 1-alpha and monocyte chemotactic factor-1 are reduced in the lung of the patient having hyperoxia or acute lung injury.
- 21. A method of reducing vascular leak, edema, or inflammation in a lung of a patient having hyperoxia or acute lung injury comprising administering umbilical cord tissue-derived cells to the patient, wherein the umbilical cord tissue-derived cells are isolated from human umbilical cord tissue substantially free of blood, are capable of self-renewal and expansion in culture, have the potential to differentiate into cells of at least a lung tissue, and do not express CD117, hTERT or telomerase, wherein the cells exert a trophic effect on the lung tissue of the patient, and wherein the levels of keratinocyte factor, gamma interferon-inducible cytokine, interleukin 1-alpha and monocyte chemotactic factor-1 are reduced in the lung of the patient having hyperoxia or acute lung injury.
Specification