PSMA binding ligand-linker conjugates and methods for using
First Claim
1. A conjugate, or a pharmaceutically acceptable salt thereof, comprising a ligand of PSMA (B), a linker (L), and a drug (D), wherein the ligand includes one or more of a carbon-sulfur double bond, a phosphorus-sulfur double bond, a phosphorus-sulfur single bond, a thioester, or a combination thereof, and wherein the linker is covalently bound to the drug and the linker is covalently bound to the ligand, and wherein the linker comprises a chain of at least seven atoms, and wherein the linker does not include a releasable linker.
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Abstract
Described herein are prostate specific membrane antigen (PSMA) binding conjugates that are useful for delivering therapeutic, diagnostic and imaging agents. Also described herein are pharmaceutical compositions containing them and methods of using the conjugates and compositions. Also described are processes for manufacture of the conjugates and the compositions containing them.
252 Citations
26 Claims
- 1. A conjugate, or a pharmaceutically acceptable salt thereof, comprising a ligand of PSMA (B), a linker (L), and a drug (D), wherein the ligand includes one or more of a carbon-sulfur double bond, a phosphorus-sulfur double bond, a phosphorus-sulfur single bond, a thioester, or a combination thereof, and wherein the linker is covalently bound to the drug and the linker is covalently bound to the ligand, and wherein the linker comprises a chain of at least seven atoms, and wherein the linker does not include a releasable linker.
Specification