Compositions and methods for virus control in Varroa mite and bees
First Claim
1. A method of reducing viral load or suppressing viral replication in a Varroa destructor mite infected by a virus, the method comprising providing to the Varroa destructor mite infected by a virus a composition comprising an effective amount of at least one double-stranded RNA (dsRNA) which comprises a nucleic acid sequence that is identical or complementary to a sequence of at least 21 contiguous nucleotides of a viral gene in said virus, wherein the dsRNA downregulates expression of said viral gene in the Varroa destructor mite, thereby reducing viral load or suppressing viral replication in the Varroa destructor mite.
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Abstract
Compositions and methods for providing viral control in Varroa mites and bees using RNA interference technology, and more particularly, prevention and treatment of viral infections in Varroa mites and bees by providing trigger polynucleotides targeting viral sequences is disclosed.
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Citations
8 Claims
- 1. A method of reducing viral load or suppressing viral replication in a Varroa destructor mite infected by a virus, the method comprising providing to the Varroa destructor mite infected by a virus a composition comprising an effective amount of at least one double-stranded RNA (dsRNA) which comprises a nucleic acid sequence that is identical or complementary to a sequence of at least 21 contiguous nucleotides of a viral gene in said virus, wherein the dsRNA downregulates expression of said viral gene in the Varroa destructor mite, thereby reducing viral load or suppressing viral replication in the Varroa destructor mite.
- 5. A method for reducing the susceptibility of a bee to a disease caused by a virus, the method comprising providing to a Varroa destructor mite infected by said virus a composition comprising an effective amount of a double-stranded RNA (dsRNA) comprising a nucleic acid sequence that is identical or complementary to a sequence of at least 21 contiguous nucleotides of a viral gene in said virus, thereby suppressing viral replication in the Varroa destructor mite and reducing the susceptibility of the bee to the disease caused by the virus.
Specification