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Biomolecule sequencing devices, systems and methods

  • US 10,557,167 B2
  • Filed: 03/02/2017
  • Issued: 02/11/2020
  • Est. Priority Date: 09/18/2013
  • Status: Active Grant
First Claim
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1. A system for detecting a biomolecule using at least one pair of nanogap electrodes, comprising:

  • a fluid flow unit comprising at least one pump for directing a plurality of monomers with reference substances bound thereto to the at least one pair of nanogap electrodes, wherein the reference substances comprise a first reference substance bound to a first monomer and a second reference substance bound to a second monomer, wherein the first reference substance is different than the second reference substance; and

    a computer processor coupled to the at least one pair of nanogap electrodes and programmed to;

    (a) measure tunneling nanocurrent signals resulting from the plurality of monomers with reference substances bound thereto using the at least one pair of nanogap electrodes, wherein the tunneling nanocurrent signals correspond to the reference substances, wherein the first reference substance and the second reference substance correspond to different tunneling nanocurrent signals; and

    (b) identify a monomer of the plurality of monomers with reference substances bound thereto based on the tunneling nanocurrent signals measured in (a).

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