Device for manipulating charged particles

• US 10,559,454 B2
• Filed: 08/08/2019
• Issued: 02/11/2020
• Est. Priority Date: 05/05/2011
• Status: Active Grant

• Current Assignee: Shimadzu Research Laboratory (Europe) Ltd. (Shimadzu Corporation)
• Original Assignee: Shimadzu Research Laboratory (Europe) Ltd. (Shimadzu Corporation)
• Inventors: Berdnikov, Alexander, Andreyeva, Alina, Giles, Roger
• Primary Examiner(s): McCormack, Jason L
• Application Number:
  US16/535,735
• Publication Number:
  US 20190371587A1
• Time in Patent Office: 187 Days
• Field of Search: 250281, 250282, 250283, 250256, 250288, 250290
• CPC Class Codes: H01J 49/0095 Particular arrangements for generating, introducing or analyzing both positive and negative analyte ions ion/ion reactions H01J49/0072
• CPC Class Codes: H01J 49/06 Electron- or ion-optical arrangements
• CPC Class Codes: H01J 49/062 Ion guides linear ion traps performing mass selection H01J49/4225, mass filters H01J49/421
• CPC Class Codes: H01J 49/065 having stacked electrodes, e.g. ring stack, plate stack

Abstract

The present invention is concerned with a device for charged particle transportation and manipulation. Embodiments provide a capability of combining positively and negatively charged particles in a single transported packet. Embodiments contain an aggregate of electrodes arranged to form a channel for transportation of charged particles, as well as a source of power supply that provides supply voltage to be applied to the electrodes, the voltage to ensure creation, inside the said channel, of a non-uniform high-frequency electric field, the pseudopotential of which field has one or more local extrema along the length of the channel used for charged particle transportation, at least, within a certain interval of time, whereas, at least one of the said extrema of the pseudopotential is transposed with time, at least within a certain interval of time, at least within a part of the length of the channel used for charged particle transportation.

Claims

1. A device for manipulating charged particles, the device comprising:

a series of electrodes arranged so as to form a channel for transportation of the charged particles;

a power supply unit adapted to provide supply voltages to said electrodes so as to create a non-uniform high-frequency electric field within said channel, the pseudopotential of said field having two or more local maxima along the length of said channel for transportation of charged particles, at least within a certain interval of time, wherein transportation of the charged particles along the length of the channel is provided by transposition of the at least two of said maxima of the pseudopotential such that the at least two of said maxima are caused to travel with time along the channel, at least within a certain interval of time and at least within a part of the length of the channel, wherein the supply voltages are high-frequency voltages;

wherein the said channel for transportation of the charged particles contains a gas

wherein the gas pressure defines viscous flow conditions;

wherein the pressure of the gas meets the condition λ

/L<

0.01, where L is a width of the transport channel and λ

is the mean free path of molecules of said viscous gas.

2. A device according to claim 1 wherein the device is an ion mobility or differential ion mobility device.

3. A device according to claim 1 wherein the channel transports ions from or within an analytical device.

4. A device according to claim 1 wherein the gas pressure is higher than 0.1 mbar.

5. A device according to claim 1, wherein at least some charged particles move through the gas with at least the same velocity as the at least two of said maxima of the pseudopotential.

6. A device according to claim 1, wherein at least some charged particles move through the gas with a velocity that is lower than the velocity of at least two of said maxima of the pseudopotential.

7. A device according to claim 1, wherein the value of an effective friction coefficient characterizing the influence of collisions with neutral gas molecules is dependent on the relative velocity between the ion and the gas flow.

8. A device according to claim 1, wherein the device is used in combination with an inlet intermediate device wherein the inlet intermediate device includes one of more of the following;

a device for transporting a beam of charged particles from a source of charged particles;

a device for accumulation and storage of charged particles;

a mass-selective device for selection of charged particles of interest;

a device for separation of charged particles based on the property of ion mobility or derivatives of ion mobility;

a cell for fragmentation of charged particles using various methods.

9. A device according to claim 1, wherein the device is used in combination with an outlet intermediate device wherein the outlet intermediate device includes one of more of the following;

a device for transporting the beam of charged particles to a detecting device;

a device for accumulation and storage of charged particles;

a mass-selective device for separation of charged particles of interest;

a device for separation of charged particles based on the property of ion mobility or derivatives of ion mobility;

a cell for fragmentation of charged particles using various methods.

10. A device according to claim 9, wherein said outlet intermediate device is configured to operate in a continuous mode.

11. A device according to claim 9, wherein said outlet intermediate device is configured to operate in a pulsed mode.

12. A device according to claim 1 located within the structure of a physical instrument in which mass-filtration of charged particles can take place.

13. A device according to claim 1, wherein additional voltages are applied to the electrodes to provide selective extraction of charged particles, said additional voltages being DC voltages, and/or quasi-static voltages, and/or AC voltages, and/or pulsed voltages, and/or high-frequency voltages.