Tissue implantable sensor with hermetically sealed housing
First Claim
1. An implantable analyte sensor, comprising:
- a biocompatible hermetically sealed housing having a size and shape suitable for implantation in tissues of a body of a subject;
a detector array comprising at least one detector and at least one membrane layer, the at least one membrane layer comprising at least;
an enzymatic material; and
a membrane structure comprising at least a cavity, the enzymatic material disposed within the cavity;
an electrical power source;
circuitry operatively connected to the detector array and configured to process at least a portion of signals generated by the at least one detector for generation of processed detector signals; and
a telemetry transmission portal configured for wireless communication with an external receiver outside of the tissues of the body when the implantable analyte sensor is implanted subcutaneously;
wherein the electrical power source and the circuitry are disposed within the housing, and the detector array and the telemetry transmission portal are disposed within or upon the housing;
wherein the at least one detector comprises a plurality of detectors;
wherein the detector array further comprises at least one electrolyte layer, at least a portion of the at least one electrolyte layer disposed between the plurality of detectors and the at least one membrane layer; and
wherein the membrane structure further comprises;
(i) a bottom wall, (ii) a top wall opposing the bottom wall, (iii) at least one side wall connected to each of the bottom wall and the top wall, the bottom wall, the top wall and the at least one side wall defining the cavity, and (iv) an aperture disposed in the top wall and in communication with the cavity, a non-enzymatic cross-linked protein material disposed within the aperture.
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Accused Products
Abstract
A tissue-implantable sensor for measurement of solutes in fluids and gases, such as oxygen and glucose, is provided. The sensor includes: i) a detector array including at least one detector; ii) a telemetry transmission portal; iii) an electrical power source; and iv) circuitry electrically connected to the detector array including signal processing means for determining an analyte level, such as glucose level, in a body fluid contacting the detectors. The sensor components are disposed in a hermetically sealed housing having a size and shape suitable for comfortable, safe, and unobtrusive subcutaneous implantation allowing for in vivo detection and long term monitoring of tissue glucose concentrations by wireless telemetry.
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Citations
31 Claims
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1. An implantable analyte sensor, comprising:
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a biocompatible hermetically sealed housing having a size and shape suitable for implantation in tissues of a body of a subject; a detector array comprising at least one detector and at least one membrane layer, the at least one membrane layer comprising at least; an enzymatic material; and a membrane structure comprising at least a cavity, the enzymatic material disposed within the cavity; an electrical power source; circuitry operatively connected to the detector array and configured to process at least a portion of signals generated by the at least one detector for generation of processed detector signals; and a telemetry transmission portal configured for wireless communication with an external receiver outside of the tissues of the body when the implantable analyte sensor is implanted subcutaneously; wherein the electrical power source and the circuitry are disposed within the housing, and the detector array and the telemetry transmission portal are disposed within or upon the housing; wherein the at least one detector comprises a plurality of detectors; wherein the detector array further comprises at least one electrolyte layer, at least a portion of the at least one electrolyte layer disposed between the plurality of detectors and the at least one membrane layer; and wherein the membrane structure further comprises;
(i) a bottom wall, (ii) a top wall opposing the bottom wall, (iii) at least one side wall connected to each of the bottom wall and the top wall, the bottom wall, the top wall and the at least one side wall defining the cavity, and (iv) an aperture disposed in the top wall and in communication with the cavity, a non-enzymatic cross-linked protein material disposed within the aperture. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13)
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14. An implantable blood glucose sensor, comprising:
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a biocompatible hermetically sealed housing having a size and shape suitable for implantation in tissues of a body of a subject; a detector array comprising at least one detector and at least one membrane layer, the at least one membrane layer comprising at least; an enzymatic material comprising a cross-linked protein material having glucose oxidase and catalase co-immobilized therein; a membrane structure comprising at least a cavity and an aperture, the aperture in communication with the cavity; a non-enzymatic cross-linked protein material disposed within the aperture, the membrane structure and the non-enzymatic cross-linked protein material configured to enclose the enzymatic material within the cavity; and an electrolyte layer disposed between the at least one detector and the membrane structure; an electrical power source; circuitry operatively connected to the detector array and configured to process at least a portion of signals generated by the at least one detector for generation of processed detector signals; and a telemetry transmission portal configured for wireless communication with an external receiver outside of the tissues of the body when the implantable blood glucose sensor is implanted subcutaneously; wherein the electrical power source and the circuitry are disposed within the housing, and the detector array and the telemetry transmission portal are disposed within or upon the housing. - View Dependent Claims (15, 16, 17, 18)
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19. An implantable analyte sensor, comprising:
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a biocompatible hermetically sealed housing having a size and shape suitable for implantation in tissues of a body of a subject; a detector array comprising at least one detector and at least one membrane layer, the at least one membrane layer comprising at least; an enzymatic material; and a membrane structure comprising at least a cavity, the enzymatic material disposed within the cavity; an electrical power source; circuitry operatively connected to the detector array and configured to process at least a portion of signals generated by the at least one detector for generation of processed detector signals; and a telemetry transmission portal configured for wireless communication with an external receiver outside of the tissues of the body when the implantable analyte sensor is implanted subcutaneously; wherein the electrical power source and the circuitry are disposed within the housing, and the detector array and the telemetry transmission portal are disposed within or upon the housing; and wherein the membrane structure further comprises an aperture in communication with the cavity, the aperture having a non-enzymatic crosslinked protein material disposed therein, the non-enzymatic cross-linked protein material configured to occlude the aperture and enable diffusion of analyte from the tissues of the body into the cavity for reaction with the enzymatic material when the implantable analyte sensor is implanted subcutaneously. - View Dependent Claims (20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31)
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Specification