Lithotripsy angioplasty devices and methods

• US 10,561,428 B2
• Filed: 04/16/2018
• Issued: 02/18/2020
• Est. Priority Date: 04/21/2017
• Status: Active Grant

• Current Assignee: Boston Scientific Scimed, Inc. (Boston Scientific Corporation)
• Original Assignee: Boston Scientific Scimed, Inc. (Boston Scientific Corporation)
• Inventors: Eggert, Joel T., Pagoria, Douglas Dean, Gessler, Raymond, Pennington, Douglas, Foster, Daniel J., Rohl, James P., Hein, Matthew
• Primary Examiner(s): Woo, Julian W
• Application Number:
  US15/954,194
• Publication Number:
  US 20180303504A1
• Time in Patent Office: 673 Days
• CPC Class Codes: A61B 17/22004 using mechanical vibrations, e.g. ultrasonic shock waves A61B17/225 takes precedence
• CPC Class Codes: A61B 17/22022 using electric discharge
• CPC Class Codes: A61B 2017/00876 magnetic
• CPC Class Codes: A61B 2017/22025 applying a shock wave A61B2017/22091 takes precedence
• CPC Class Codes: A61B 2017/22051 with an inflatable part, e.g. balloon, for positioning, blocking, or immobilisation A61B2017/22048, A61B2017/3486 take precedence
• CPC Class Codes: A61B 2017/22061 for spreading elements apart
• CPC Class Codes: A61B 2017/22062 to be filled with liquid
• CPC Class Codes: A61B 34/73 Manipulators for magnetic surgery
• CPC Class Codes: A61L 29/02 Inorganic materials
• CPC Class Codes: A61M 2025/1086 having a special balloon surface topography, e.g. pores, protuberances, spikes or grooves
• CPC Class Codes: A61M 2205/0272 Electro-active or magneto-active materials
• CPC Class Codes: A61M 25/10 Balloon catheters A61M25/0125 takes precedence; embolectomy A61B17/22032; retractors A61B17/02; inflatable balloons for placing stents or stent-grafts A61F2/958 ; stomach balloons for treatment of obesity A61F5/0003; oesophagal tubes A61J15/00
• CPC Class Codes: A61M 25/104 used for angioplasty

Abstract

An example method for treating a blood vessel may include disposing a medical device within the blood vessel at a position adjacent to a lesion. The medical device may include an elongate shaft having a distal end region, a balloon coupled to the distal end region, and an iron-containing fluid disposed within the balloon. The method may also include inflating the balloon to a first pressure, delivering a plurality of electromagnetic pulses to the iron-containing fluid, and inflating the balloon to a second pressure greater than the first pressure.

Claims

1. A method for treating a blood vessel, the method comprising:

disposing a medical device within the blood vessel at a position adjacent to a lesion, the medical device comprising;

an elongate shaft having a distal end region, an electrode coupled to the shaft and positioned within the balloon,

a balloon coupled to the distal end region, and

an iron-containing fluid disposed within the balloon;

inflating the balloon to a first pressure;

delivering a plurality of electromagnetic pulses from the electrode to the iron-containing fluid; and

inflating the balloon to a second pressure greater than the first pressure.

2. The method of claim 1, wherein the iron-containing fluid includes iron nanoparticles.

3. The method of claim 2, wherein at least some of the iron nanoparticles have a conical shape.

4. The method of claim 2, wherein delivering a plurality of electromagnetic pulses to the balloon moves at least some of the iron nanoparticles toward a surface of the balloon.

5. The method of claim 1, wherein an electrode is coupled to the shaft and positioned within the balloon, and wherein delivering a plurality of electromagnetic pulses to the iron-containing fluid includes activating the electrode.

6. The method of claim 1, wherein the balloon further comprises a reinforcing member.

7. The method of claim 1, wherein inflating the balloon to a first pressure includes inflating the balloon to a pressure of 3-5 atmospheres.

8. The method of claim 1, wherein inflating the balloon to a second pressure greater than the first pressure includes inflating the balloon to a pressure of 5-9 atmospheres.

9. A method for treating a blood vessel, the method comprising:

disposing a lithotripsy angioplasty medical device within the blood vessel at a position adjacent to a calcified lesion, the lithotripsy angioplasty medical device comprising;

an elongate shaft having a distal end region,

a balloon coupled to the distal end region,

an iron-containing fluid disposed within the balloon, and

an electrode coupled to the shaft;

inflating the balloon to a first pressure;

transferring force from the balloon to the calcified lesion by delivering electromagnetic pulses with the electrode to activate the iron-containing fluid; and

inflating the balloon to a second pressure greater than the first pressure.

10. The method of claim 9, wherein the iron-containing fluid includes iron nanoparticles.

11. The method of claim 10, wherein at least some of the iron nanoparticles have a conical shape.

12. The method of claim 11, wherein transferring force from the balloon to the calcified lesion by delivering electromagnetic pulses with the electrode to activate the iron-containing fluid moves at least some of the iron nanoparticles toward a surface of the balloon.

13. The method of claim 9, wherein the electrode is positioned within the balloon.

14. The method of claim 9, wherein the balloon further comprises a reinforcing member.

15. The method of claim 9, wherein inflating the balloon to a first pressure includes inflating the balloon to a pressure of 3-5 atmospheres.

16. The method of claim 9, wherein inflating the balloon to a second pressure greater than the first pressure includes inflating the balloon to a pressure of 5-9 atmospheres.

17. A lithotripsy angioplasty medical device, comprising:

an elongate shaft having a distal end region;

a balloon coupled to the distal end region;

an iron-containing fluid disposed within the balloon;

an electrode coupled to the shaft and positioned within the balloon, the electrode being configured to deliver electromagnetic pulses to the fluid;

wherein the balloon is configured to shift between a first unexpanded configuration, a second configuration when the balloon is partially expanded into contact with a target region, and an expanded configuration.

18. The lithotripsy angioplasty medical device of claim 17, wherein the iron-containing fluid includes iron nanoparticles.

19. The lithotripsy angioplasty medical device of claim 18, wherein at least some of the iron nanoparticles have a conical shape.

20. The lithotripsy angioplasty medical device of claim 17, wherein the balloon further comprises a reinforcing member.