Systems and methods for programming and operating deep brain stimulation arrays

• US 10,561,848 B2
• Filed: 10/12/2016
• Issued: 02/18/2020
• Est. Priority Date: 10/13/2015
• Status: Active Grant

• Current Assignee: Regents of The University of Minnesota (University of Minnesota)
• Original Assignee: Regents of The University of Minnesota (University of Minnesota)
• Inventors: Xiao, YiZi, Pena, Edgar, Johnson, Matthew Douglas
• Primary Examiner(s): Stice, Paula J
• Application Number:
  US15/291,628
• Publication Number:
  US 20170100601A1
• Time in Patent Office: 1,224 Days
• CPC Class Codes: A61N 1/0534 Electrodes for deep brain stimulation
• CPC Class Codes: A61N 1/36067 Movement disorders, e.g. tremor or Parkinson disease stimulating motor muscle A61N1/36003
• CPC Class Codes: A61N 1/36082 Cognitive or psychiatric applications, e.g. dementia or Alzheimer's disease
• CPC Class Codes: A61N 1/36146 specified by the stimulation parameters
• CPC Class Codes: A61N 1/37247 User interfaces, e.g. input or presentation means

Abstract

Systems, methods and apparatus for determining and/or programming stimulation settings for a pulse generator capable of steering current to a deep brain stimulation array are disclosed. Individual patient brain geometry and lead specific geometry data can be used to generate a maximum activation function curve. Optimization methods can be used to find stimulation settings that are as close as possible to achieving the value of the maximum activation function curve.

Claims

1. A method for determining a stimulation setting for each electrode in a deep brain stimulation array including one or more electrodes, the method comprising:

using brain geometry data to generate a discrete brain geometry grid;

identifying one or more grid points in the discrete brain geometry grid, the one or more grid points representing a target tissue to be activated by stimulation through the one or more electrodes;

calculating a maximum activation function value for each of the one or more grid points using an estimated voltage distribution of the stimulation of the one or more electrodes;

constructing a maximum curve for the discrete brain geometry grid from the maximum activation function value of each of the one or more grid points;

optimizing a set of stimulation settings for each of the one or more electrodes using one or more optimization methods such that an actual activation curve for the discrete brain geometry grid is as close as possible to the maximum curve of the discrete brain geometry grid; and

providing, to a pulse generator capable of delivering therapy via each of the one or more electrodes, the set of stimulation settings for each electrode.

2. The method of claim 1, wherein the identifying comprises:

receiving brain geometry data;

receiving lead geometry data; and

generating, from the brain geometry data and the lead geometry data, the one or more grid points representing the target tissue to be activated.

3. The method of claim 1, wherein the optimizing comprises minimizing a maximum deviation between the maximum activation function value and the actual activation function value for each of the one or more grid points.

4. The method of claim 1, wherein the optimizing comprises minimizing a difference between the maximum activation function value and the actual activation function value for each of the one or more grid points.

5. The method of claim 1, wherein the optimizing comprises minimizing a square of a difference between the maximum activation function value and the actual activation function value for each of the one or more grid points.

6. The method of claim 1, wherein the stimulation settings comprise electrical pulse amplitudes.

7. The method of claim 1, wherein the stimulation settings comprise electrical pulse widths.

8. The method of claim 1, wherein the optimizing comprises using an optimization routine.

9. The method of claim 1, further comprising optimizing, using a plurality of optimization routines, a plurality of sets of stimulation settings for each electrode.

10. The method of claim 1, wherein the stimulation settings are configured to avoid activation of non-target tissue such that the method further comprises:

identifying one or more grid points representing non-target tissue to be avoided when stimulating through the one or more electrodes;

optimizing a set of stimulation settings for each of the one or more electrodes such that an actual activation function value of the one or more grid points is as close as possible to the minimum activation function value calculated for each of the one or more grid points; and

including the set of stimulation settings for at least one of the one or more electrodes in the providing to the pulse generator.