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Treatment of Sirtuin (SIRT) related diseases by inhibition of natural antisense transcript to a Sirtuin (SIRT)

  • US 10,563,202 B2
  • Filed: 05/01/2015
  • Issued: 02/18/2020
  • Est. Priority Date: 07/24/2009
  • Status: Active Grant
First Claim
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1. A method of upregulating a function of and/or the expression of a Sirtuin (SIRT) polynucleotide having SEQ ID NOS:

  • 1, 3 or 4 in patient cells or tissues in vivo or in vitro comprising;

    contacting said cells or tissues with at least one single-stranded antisense oligonucleotide 14 to 24 nucleotides in length wherein said at least one oligonucleotide is 100% complementary and hybridizes to a complementary polynucleotide comprising 12 to 24 nucleotides within nucleotides 1 to 1028 of SEQ ID NO;

    5 or nucleotides 1 to 352 and 373 to 429 of SEQ ID NO;

    6, or nucleotides 1 to 156 of SEQ ID NO;

    7 or nucleotides 269 to 593 of SEQ ID NO;

    8, 1 to 373 of SEQ ID NO;

    9, 1 to 589 of SEQ ID NO;

    12, and 1 to 4026 of SEQ ID NO;

    14;

    thereby upregulating a function of and/or the expression of the Sirtuin (SIRT) polynucleotide in patient cells or tissues in vivo or in vitro.

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