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Breath analysis systems and methods for asthma, tuberculosis and lung cancer diagnostics and disease management

  • US 10,568,541 B2
  • Filed: 11/30/2009
  • Issued: 02/25/2020
  • Est. Priority Date: 12/01/2008
  • Status: Active Grant
First Claim
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1. A method for detecting whether a subject has a respiratory disease or monitoring a subject with a respiratory disease said method comprising:

  • receiving, at a portable apparatus having a gas chromatograph coupled to a detector array, ambient air to be inhaled by said subject, wherein the portable apparatus includes the gas chromatograph and the detector array replaceably mounted to a substrate of the portable apparatus;

    filtering, by a volatile organic compound (VOC) filter, the ambient air to remove at least a portion of background VOC content in the ambient air;

    further filtering, by a nitric oxide (NO) filter, the ambient air to remove at least a portion of background NO content from the ambient air;

    providing, at the portable apparatus, at least a portion of the ambient air to said subject to be inhaled;

    receiving, at the portable apparatus, breath exhaled from said subject;

    contacting the breath exhaled from said subject with the gas chromatograph mounted to the substrate of the portable apparatus;

    producing, by the detector array coupled to the gas chromatograph and mounted to the substrate of the portable apparatus, an indicator based on the exhaled breath from said subject, the indicator being produced based at least in part on one or more analytes in the breath exhaled from said subject, and the indicator being indicative of one or more biomarkers in the exhaled breath; and

    analyzing, by an analysis circuit disposed on said portable apparatus, said indicator to determine whether said subject has asthma, wherein the determination is made based on an NO concentration level in conjunction with VOC detection from the breath exhaled from said subject.

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