Fluid handling cassette

• US 10,568,555 B2
• Filed: 03/26/2015
• Issued: 02/25/2020
• Est. Priority Date: 02/14/2005
• Status: Active Grant

• Current Assignee: OptiScan Biomedical Corporation
• Original Assignee: OptiScan Biomedical Corporation
• Inventors: Gable, Jennifer H., Braig, James R., Li, Kenneth I., Wechsler, Mark, Zheng, Peng, Keenan, Richard
• Primary Examiner(s): Dougherty, Sean P
• Assistant Examiner(s): Melhus, Benjamin S
• Application Number:
  US14/670,073
• Publication Number:
  US 20150366495A1
• Time in Patent Office: 1,797 Days
• CPC Class Codes: A61B 10/0064 for taking sweat or sebum samples measuring sweat production A61B5/4266
• CPC Class Codes: A61B 2560/0443 Modular apparatus
• CPC Class Codes: A61B 5/0071 by measuring fluorescence emission
• CPC Class Codes: A61B 5/0075 by spectroscopy, i.e. measuring spectra, e.g. Raman spectroscopy, infrared absorption spectroscopy A61B5/0071 takes precedence
• CPC Class Codes: A61B 5/0084 for introduction into the body, e.g. by catheters A61B5/1459 takes precedence
• CPC Class Codes: A61B 5/0086 using infrared radiation
• CPC Class Codes: A61B 5/1411 by percutaneous method, e.g. by lancet
• CPC Class Codes: A61B 5/1427 Multiple blood sampling, e.g. at periodic or pre-established intervals
• CPC Class Codes: A61B 5/1451 for interstitial fluid
• CPC Class Codes: A61B 5/14517 for sweat
• CPC Class Codes: A61B 5/14532 for measuring glucose, e.g. by tissue impedance measurement
• CPC Class Codes: A61B 5/14535 for measuring haematocrit
• CPC Class Codes: A61B 5/14546 for measuring analytes not otherwise provided for, e.g. ions, cytochromes
• CPC Class Codes: A61B 5/1455 using optical sensors, e.g. spectral photometrical oximeters
• CPC Class Codes: A61B 5/15003 for venous or arterial blood
• CPC Class Codes: A61B 5/150213 Venting means
• CPC Class Codes: A61B 5/150221 Valves
• CPC Class Codes: A61B 5/150229 Pumps for assisting the blood sampling
• CPC Class Codes: A61B 5/150267 Modular design or construction, i.e. subunits are assembled separately before being joined together or the device comprises interchangeable or detachable modules
• CPC Class Codes: A61B 5/150358 Strips for collecting blood, e.g. absorbent optical reagent test strips G01N21/8483; chemical reagent test strips G01N33/4875, G01N33/52
• CPC Class Codes: A61B 5/150755 : Blood sample preparation for further analysis, e.g. by separating blood components or by mixing
• CPC Class Codes: A61B 5/150862 : intermediate range, e.g. within room or building
• CPC Class Codes: A61B 5/150992 : Blood sampling from a fluid line external to a patient, such as a catheter line, combined with an infusion line; blood sampling from indwelling needle sets, e.g. sealable ports, luer couplings, valves tubing connectors and couplings A61M39/00
• CPC Class Codes: A61B 5/153 : Devices specially adapted for taking samples of venous or arterial blood, e.g. with syringes
• CPC Class Codes: A61B 5/155 : Devices specially adapted for continuous or multiple sampling, e.g. at predetermined intervals devices loaded with multiple lancets simultaneously A61B5/15146
• CPC Class Codes: A61B 5/157 : Devices characterised by integrated means for measuring characteristics of blood
• CPC Class Codes: A61B 5/4839 : combined with drug delivery
• CPC Class Codes: A61M 2205/12 : with interchangeable cassettes forming partially or totally the fluid circuit
• CPC Class Codes: A61M 2205/3306 : Optical measuring means
• CPC Class Codes: A61M 2230/20 : Blood composition characteristics
• CPC Class Codes: A61M 2230/201 : Glucose concentration
• CPC Class Codes: A61M 5/14212 : Pumping with an aspiration and an expulsion action
• CPC Class Codes: A61M 5/14232 : Roller pumps
• CPC Class Codes: A61M 5/16854 : by monitoring line pressure
• CPC Class Codes: A61M 5/1723 : using feedback of body parameters, e.g. blood-sugar, pressure measurement of body parameters A61B5/00
• CPC Class Codes: A61M 5/365 : Air detectors A61M5/1684 takes precedence; in extracorporeal blood circuits A61M1/3626
• CPC Class Codes: A61M 5/38 : using hydrophilic or hydrophobic filters
• CPC Class Codes: G01N 2021/3595 : using FTIR
• CPC Class Codes: G01N 21/03 : Cuvette constructions
• CPC Class Codes: G01N 21/3577 : for analysing liquids, e.g. polluted water
• CPC Class Codes: G01N 2201/02 : Mechanical
• CPC Class Codes: G01N 2201/061 : Sources
• CPC Class Codes: Y10T 137/4478 : Line condition change responsive
• CPC Class Codes: Y10T 137/7722 : Line condition change responsive valves
• CPC Class Codes: Y10T 137/86485 : Line condition change responsive release of valve
• CPC Class Codes: Y10T 436/111666 : Utilizing a centrifuge or compartmented rotor
• CPC Class Codes: Y10T 436/2575 : Volumetric liquid transfer

Abstract

A fluid handling module that is removably engageable with a bodily fluid analyzer is provided. The module may comprise a fluid handling element, and a fluid component separator that is accessible via the fluid handling element and configured to separate at least one component of a bodily fluid transported to the fluid component separator. The fluid handling element may have at least one control element interface.

Claims

1. A fluid handling and analysis system comprising:

a main analysis and control instrument comprising a reusable optical sensor; and

a disposable fluid handling module removably engageable with said main instrument;

said main instrument further comprising a bodily fluid analyzer and at least one control element configured to mechanically interface with the disposable fluid handling module to control fluid flow through the disposable fluid handling module when the disposable fluid handling is removably engaged with the main instrument;

said disposable fluid handling module further comprising a sample element and at least one fluid handling element, wherein said sample element is accessible via said fluid handling element and integrated therein to allow analysis of a fluid portion within a sample chamber of the sample element, said disposable fluid handling module further comprising a window positioned adjacent the reusable optical sensor and in an optical path for detection of fluid flow within the disposable fluid handling module, the optical path traversing the fluid at a position separate from the analysis portion within and proximate to an inlet of the disposable fluid handing module; and

said at least one fluid handling element having a control interface configured to engage said at least one control element when said main instrument and said disposable fluid handling module are removably engaged.

2. The system of claim 1, wherein said at least one fluid handling element comprises a fluid passageway.

3. The system of claim 2, wherein said at least one control element comprises a valve actuator.

4. The system of claim 1, wherein said at least one fluid handling element comprises a syringe.

5. The system of claim 4, wherein said at least one control element comprises a syringe drive.

6. The system of claim 1, wherein said at least one control element is operatively configured to control fluid flow in said at least one fluid handling element.

7. The system of claim 1, wherein said at least one control element is operatively configured to control fluid communication between said sample element and said at least one fluid handling element.

8. The system of claim 1, wherein said disposable fluid handling module further comprises a module housing wherein said at least one control element interface is accessible to said at least one control element of said main instrument through said module body.

9. The system of claim 8, wherein said module body encloses said at least one fluid handling element, said module body further comprising at least one opening operably positioned to allow access to said at least one control element interface.

10. The system of claim 9, wherein said at least one control element interface comprises a passageway portion extending across said at least one opening in said module body.

11. The system of claim 8, wherein said sample element comprises a supply passage extending to a supply opening and a vent passage extending to a vent opening.

12. The system of claim 11, wherein said supply passage and said vent passage are in fluid communication.

13. The system of claim 8, wherein said sample element is located on said module housing.

14. The system of claim 1, wherein said sample element is a cuvette.

15. The system of claim 1, wherein said sample element comprises a membrane.

16. The system of claim 1, wherein said sample element comprises a fluid component separator comprising a filter.

17. The system of claim 16, wherein said fluid component separator further comprises a disposable portion of the disposable fluid handling module.

18. The system of claim 1, wherein said sample element stores one or more reagents.