Drug-eluting medical implants
First Claim
Patent Images
1. A medical implant comprising:
- a tubular structure comprising struts, wherein said tubular structure is biostable;
a first conformal coating comprising a first polymeric material at least partially coating said struts; and
a second conformal coating at least partially coating said first conformal coating, said second conformal coating comprising pacilitaxel as a sole therapeutic agent, wherein said tubular structure is characterized by a surface area of from 11.4 to 53.8 mm2/mm length of the tubular structure.
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Abstract
Disclosed are self-expanding medical implants for placement within a lumen of a patient. The implants comprise a woven or non-woven structure having a substantially tubular configuration, and are designed to be low-profile such that they are deliverable with a small diameter catheter. The implants have a high recoverability and desired mechanical properties.
488 Citations
16 Claims
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1. A medical implant comprising:
- a tubular structure comprising struts, wherein said tubular structure is biostable;
a first conformal coating comprising a first polymeric material at least partially coating said struts; and
a second conformal coating at least partially coating said first conformal coating, said second conformal coating comprising pacilitaxel as a sole therapeutic agent, wherein said tubular structure is characterized by a surface area of from 11.4 to 53.8 mm2/mm length of the tubular structure. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9)
- a tubular structure comprising struts, wherein said tubular structure is biostable;
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10. A medical implant comprising:
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a tubular structure comprising struts, wherein said tubular structure is biostable; a first conformal coating comprising a first polymeric material and at least partially coating said struts; and a second conformal coating at least partially coating said first conformal coating, said second conformal coating comprising a second polymeric material and an amount of paclitaxel as a single therapeutic agent; wherein said tubular structure is characterized by a surface area, wherein the amount of paclitaxel is within the range of about 0.002 to about 0.175 micrograms per square millimeter of said surface area, and wherein said tubular structure has a surface area within the range of about 11.4 to about 53.8 square millimeters per millimeter length of said tubular structure. - View Dependent Claims (11, 12, 13, 14, 15, 16)
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Specification