Soluble hybrid Fcγ receptors and related methods
First Claim
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1. An isolated nucleic acid molecule encoding a polypeptide selected from the group consisting of:
- a) amino acid residues 43-310 of SEQ ID NO;
42;
b) amino acid residues 21-286 of SEQ ID NO;
44; and
c) amino acid residues 21-286 of SEQ ID NO;
46;
wherein said polypeptide is capable of specifically binding the Fc region of IgG.
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Abstract
Disclosed are soluble hybrid Fcγ receptor (FcγR) polypeptide compositions and related methods of using such polypeptides to treat IgG-mediated and immune complex-mediated inflammation. Also disclosed are related compositions and methods for producing the soluble hybrid FcγR polypeptides.
3 Citations
9 Claims
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1. An isolated nucleic acid molecule encoding a polypeptide selected from the group consisting of:
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a) amino acid residues 43-310 of SEQ ID NO;
42;b) amino acid residues 21-286 of SEQ ID NO;
44; andc) amino acid residues 21-286 of SEQ ID NO;
46;wherein said polypeptide is capable of specifically binding the Fc region of IgG. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9)
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Specification