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Methods and compositions for RNA-directed target DNA modification and for RNA-directed modulation of transcription

  • US 10,570,419 B2
  • Filed: 04/11/2019
  • Issued: 02/25/2020
  • Est. Priority Date: 05/25/2012
  • Status: Active Grant
First Claim
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1. A composition comprising a DNA-targeting RNA that comprises:

  • (i) a targeter-RNA comprising a nucleotide sequence that is complementary to a target sequence of a target DNA, and(ii) an activator-RNA that is capable of hybridizing with the targeter-RNA to form a double-stranded duplex,wherein (i) and (ii) are covalently linked,wherein the DNA-targeting RNA is capable of forming a complex with a Cas9 protein and hybridization of the targeter-RNA to the target sequence is capable of targeting the Cas9 protein to the target DNA.

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