Systems and methods for biological analysis
First Claim
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1. A method for detecting at least a portion of a biological molecule, comprising:
- (a) providing an array of sensors, wherein a sensor of said array of sensors comprises a transmitter electrode and a receiver electrode, which transmitter electrode or receiver electrode is coupled to at least another sensor of said array of sensors;
(b) directing a solution containing or suspected of containing said biological molecule to said array of sensors under conditions sufficient to bring said biological molecule to said sensor;
(c) using said transmitter electrode and said receiver electrode to measure a change in impedance in an electrical flow path comprising said at least said portion of said biological molecule; and
(d) using said change in impedance to detect said at least said portion of said biological molecule.
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Accused Products
Abstract
Provided herein are devices and methods suitable for sequencing, amplifying, analyzing, and performing sample preparation procedures for nucleic acids and other biomolecules.
284 Citations
25 Claims
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1. A method for detecting at least a portion of a biological molecule, comprising:
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(a) providing an array of sensors, wherein a sensor of said array of sensors comprises a transmitter electrode and a receiver electrode, which transmitter electrode or receiver electrode is coupled to at least another sensor of said array of sensors; (b) directing a solution containing or suspected of containing said biological molecule to said array of sensors under conditions sufficient to bring said biological molecule to said sensor; (c) using said transmitter electrode and said receiver electrode to measure a change in impedance in an electrical flow path comprising said at least said portion of said biological molecule; and (d) using said change in impedance to detect said at least said portion of said biological molecule. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 19, 20)
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18. A method for detecting at least a portion of a biological molecule, comprising:
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(a) providing an array of sensors, wherein a sensor of said array of sensors comprises a transmitter electrode and a receiver electrode, which transmitter electrode or receiver electrode is coupled to at least another sensor of said array of sensors; (b) directing a solution containing or suspected of containing said biological molecule to said array of sensors under conditions sufficient to bring said biological molecule to said sensor; (c) using said transmitter electrode and said receiver electrode to measure one or more signals that are indicative of a change in impedance in an electrical flow path comprising said at least said portion of said biological molecule, wherein said electrical flow path is between said transmitter electrode and said receiver electrode; and (d) using said one or more signals to detect said at least said portion of said biological molecule. - View Dependent Claims (21, 22, 23, 24, 25)
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Specification