System and method for automated dosage calculation and patient treatment life cycle

• US 10,572,628 B2
• Filed: 03/11/2015
• Issued: 02/25/2020
• Est. Priority Date: 07/13/2011
• Status: Active Grant

• Current Assignee: The Sottopelle Group LLC
• Original Assignee: The Sottopelle Group LLC
• Inventors: Tutera, Gino
• Primary Examiner(s): Tomaszewski, Michael
• Assistant Examiner(s): Muqueeth, Mohmad
• Application Number:
  US15/125,529
• Publication Number:
  US 20170091417A1
• Time in Patent Office: 1,812 Days
• CPC Class Codes: G06Q 10/00 Administration; Management
• CPC Class Codes: G16H 10/20 for electronic clinical trials or questionnaires
• CPC Class Codes: G16H 10/60 for patient-specific data, e.g. for electronic patient records
• CPC Class Codes: G16H 20/10 relating to drugs or medications, e.g. for ensuring correct administration to patients
• CPC Class Codes: G16H 40/20 for the management or administration of healthcare resources or facilities, e.g. managing hospital staff or surgery rooms
• CPC Class Codes: G16H 40/67 for remote operation
• CPC Class Codes: G16H 50/20 for computer-aided diagnosis, e.g. based on medical expert systems
• CPC Class Codes: G16H 50/70 for mining of medical data, e.g. analysing previous cases of other patients

Abstract

A system and method for automatically calculating an accurate recommended dosage for hormone replacement therapy and automating the life cycle of a patient'"'"'s treatment over time. The system and method can automatically acquire relevant patient parameters and apply a consistent formulaic approach to help reduce incorrect dosage determinations. A pellet insertion size may be determined and documented based on a calculated dosage, and an insertion side and lot numbers may be tracked and managed. In addition, corresponding revenues may be tracked and profitability may be reported for hormone replacement therapy practices.

Claims

1. A computer-implemented method of providing a dosage and a patient treatment life-cycle comprising:

receiving, by a computerized device comprising a processor, an input device, and a display screen, an input signal of a user indicating an input directed to a patient sex and a patient status, wherein the patient status is automatically determined by the processor and includes at least one of a new patient, a returning patient and a booster patient;

determining by the processor an effective estradiol dosage and an effective testosterone dosage using dosage calculation methods selected based on the patient status, automated female input parameters, and female tracking parameters in response to receiving an input indicating that the patent sex is female;

determining by the processor an effective testosterone dosage using dosage calculation methods selected based on the patient status, automated male input parameters, and male tracking parameters in response to receiving an input indicating that the patient sex is male;

displaying, on the display screen, the determined effective dosages; and

administering a pellet comprising at least one of the determined effective dosages to the patient.

2. The method according to claim 1, wherein the automated female input parameters and the automated male input parameters comprise at least one of a physical activity level, a quantity of patient visits, patient age, patient height, weight, race, number of pregnancies, number of live births, number of abortions, history of renal disease, history of active liver disease, hysterectomy, history of cervical cancer, history of ovarian cancer, history of fibrocystic breast disease, history of breast cancer, current follicle stimulating hormone (FSH) level, current testosterone level, current estradiol level, current non-pellet estradiol dose, current non-pellet testosterone dose, history of acne, history of facial hair, history of hair loss, history of prostate cancer, history of polycystic ovary syndrome (PCOS), history of hysterectomy, history of heavy menses, and history of metabolic syndrome.

3. The method according to claim 2, further comprising automatically calculating, by the processor, at least one of the patient age based on a date of birth entered into the input device by the user and the patient height based on a height parameter entered into the input device by the user.

4. The method according to claim 2, wherein the dosage method for a female booster and return patient further comprises:

receiving, by the processor, female non-pellet testosterone usage of the patient, a pre-menopausal or post-menopausal patient status, an estradiol level of the patient, and a migraine status of the patient;

determining, by the processor, an estradiol dosage=0 in response to receiving an estradiol level of the patient that is greater than 10 milligrams and a migraine status of the patient that indicates that the patient has migraines; and

determining, by the processor, a testosterone dosage=0 in response to receiving a female non-pellet testosterone usage of the patent that is greater than zero milligrams.

5. The method according to claim 1, wherein determining the effective dosages is based on input parameters comprising at least one of a physical activity level, a quantity of patient visits, patient age, patient height, weight, race, number of pregnancies, number of live births, number of abortions, history of renal disease, history of active liver disease, hysterectomy, history of cervical cancer, history of ovarian cancer, history of fibrocystic breast disease, history of breast cancer, current follicle stimulating hormone (FSH) level, current testosterone level, current estradiol level, current non-pellet estradiol dose, current non-pellet testosterone dose, history of acne, history of facial hair, history of hair loss, history of prostate cancer, history of polycystic ovary syndrome (PCOS), history of hysterectomy, history of heavy menses, and history of metabolic syndrome.

6. The method according to claim 1, further comprising displaying a past insertion history on the display screen corresponding to the patient, wherein the past insertion history includes at least one of a previous insertion date, a previous testosterone dose, a previous estradiol dose, a pellet insertion location, and a pellet insertion side.

7. The method according to claim 6, further comprising identifying, using the past insertion history, an insertion time frame for return dosing for at least one of the returning patient and the booster patient.

8. The method according to claim 6, further comprising displaying the previous insertion date, the previous testosterone dose, the previous estradiol dose, the pellet insertion location, and the pellet insertion side on the display screen for the user at a time of insertion.

9. The method according to claim 6, further comprising identifying, by the user, a new pellet insertion location based on at least one of the pellet insertion location, the previous insertion date, the previous testosterone dose and the previous estradiol dose provided by the past insertion history on the display screen.

10. The method according to claim 1, wherein using dosage calculation methods selected based on the female tracking parameters and the male tracking parameters comprises tracking at least one of a pellet insertion location, a pellet insertion side, a pellet dose, a pellet lot number, an insertion note, a previous testosterone dose, and a previous estradiol dose.

11. The method according to claim 10, further comprising automatically displaying at least one of the previous estradiol dose and the previous testosterone dose on the display screen of the input device, wherein the previous estradiol dose and the previous testosterone dose are based on a last full dosage, the last full dosage being different from at least one previous effective dosage.

12. The method according to claim 10, wherein tracking the pellet insertion location and the pellet insertion side is based on historical insertion information including at least one of a hip location, an abdominal location, a left side, and a right side;

and

wherein, based on the historical insertion information, the pellet insertion location and the pellet insertion side are automatically suggested by the processor.

13. The method according to claim 12, further comprising providing an option to the user to manually input at least one of the pellet insertion location and the pellet insertion side, the at least one of the pellet insertion location and the pellet insertion side being different from the pellet insertion location and the pellet insertion side automatically suggested by the processor.

14. The method according to claim 10, wherein tracking the pellet lot number comprises entering one or more corresponding lot numbers into at least one lot number field provided on the display screen of the input device.

15. The method according to claim 1, further comprising determining by the processor an estradiol pellet size insertion corresponding to the effective estradiol dosage and a testosterone pellet size insertion corresponding to the effective testosterone dosage using a pellet allocation algorithm, wherein a quantity of the estradiol pellet size insertion and the testosterone pellet size insertion are minimized.

16. The method according to claim 15, further comprising providing an option to the user to manually input at least one of the estradiol pellet size insertion and the testosterone pellet size insertion, the at least one of the estradiol pellet size insertion and the testosterone pellet size insertion being different from the estradiol pellet size insertion and the testosterone pellet size insertion determined by the pellet allocation algorithm.

17. The method according to claim 15, further comprising:

ordering, by the processor, a plurality of pellet sizes from largest to smallest;

subtracting, by the processor, a largest of the plurality of pellet sizes from the effective dosage; and

if a result of the subtraction is greater than zero, assigning, by the processor, the largest of the plurality of pellet sizes as the estradiol pellet size insertion or the testosterone pellet size insertion;

if a result of the subtraction is less than zero, subtracting, by the processor, a next smallest one of the plurality of pellet sizes from the effective dosage until the result is greater than zero;

calculating, by the processor, an absolute value of the result of the subtraction that is less than zero and an absolute value of the result of the subtraction that is greater than zero; and

assigning, by the processor, one of the plurality of pellet sizes as the estradiol pellet size insertion or the testosterone pellet size insertion corresponding to the result having a lesser absolute value.

18. The method according to claim 1, further comprising:

displaying, by the display, an estradiol pellet size insertion corresponding to the effective estradiol dosage and a testosterone pellet size insertion corresponding to the effective testosterone dosage;

receiving, by the input device, another input signal of the user indicating at least one of an increase and a decrease in at least one of the estradiol pellet size insertion and the testosterone pellet size insertion; and

calculating, by the processor in real-time, an updated effective estradiol dosage and an updated effective testosterone dosage based on the input signal of the user.

19. The method according to claim 1, wherein using the dosage calculation method comprises incorporating a return visit associated with the patient to determine at least one of the effective estradiol dosage and the effective testosterone dosage.

20. The method according to claim 1, further comprising providing a comprehensive toolkit on the input device, the comprehensive toolkit kit comprising at least one of an ancillary support function, a patient consult request a patient consult response, an article, a video, a form, news, an update, a product purchase order, a financial report, and an assistant assignment related to the dosage and patient treatment life-cycle.

21. The method according to claim 1, further comprising:

tracking, using the processor, a profitability metric for the patient; and

generating a report corresponding to the profitability metric over time.

22. A computer-implemented method of providing a dosage and a patient treatment life-cycle comprising:

receiving, by a computerized device comprising a processor, an input device, and a display screen, an input signal of a user indicating an input directed to a patient sex and a patient status, wherein the patient status is automatically determined by the processor and includes at least one of a new patient, a returning patient and a booster patient;

determining by the processor at least one of an effective estradiol dosage and an effective testosterone dosage using a calculation method selected based on the patient status, automated input parameters, and tracking parameters;

determining, by the processor, an estradiol pellet size insertion corresponding to the effective estradiol dosage and a testosterone pellet size insertion corresponding to the effective testosterone dosage using a pellet allocation algorithm, wherein a quantity of the estradiol pellet size insertion and the testosterone pellet size insertion are minimized;

displaying, on the display screen, the determined effective dosages, the estradiol pellet size, and the testosterone pellet size; and

administering a pellet comprising at least one of the determined effective dosages to the patient.

23. The method according to claim 22, further comprising:

determining, by the processor, the effective estradiol dosage and the effective testosterone dosage if the patient sex is female; and

determining, by the processor, the effective testosterone dosage if the patient sex is male.

24. The method according to claim 22, wherein the automated input parameters comprise at least one of a physical activity level, a quantity of patient visits, patient age, patient height, weight, race, number of pregnancies, number of live births, number of abortions, history of renal disease, history of active liver disease, hysterectomy, history of cervical cancer, history of ovarian cancer, history of fibrocystic breast disease, history of breast cancer, current follicle stimulating hormone (FSH) level, current testosterone level, current estradiol level, current non-pellet estradiol dose, current non-pellet testosterone dose, history of acne, history of facial hair, history of hair loss, history of prostate cancer, history of polycystic ovary syndrome (PCOS), history of hysterectomy, history of heavy menses, and history of metabolic syndrome.

25. The method according to claim 24, further comprising automatically calculating, by the processor, at least one of the patient age based on a date of birth entered into the input device by the user and the patient height based on a height parameter entered into the input device by the user.

26. The method according to claim 24, wherein the dosage method for a female booster and return patient further comprises:

receiving, by the processor, female non-pellet testosterone usage, a pre-menopausal or post-menopausal patient status, an estradiol level of the patient, and a migraine status of the patient;

determining, by the processor, an estradiol dosage=0 in response to receiving an estradiol level of the patient that is greater than 10 milligrams and a migraine status of the patient that indicates that the patient has migraines; and

if patient uses non-pellet testosterone, determining, by the processor, a testosterone dosage=0 in response to receiving a female non-pellet testosterone usage of the patent that is greater than zero milligrams.

27. The method according to claim 22, wherein using dosage calculation methods selected based on the tracking parameters includes tracking at least one of a pellet insertion location, a pellet insertion side, a pellet dose, a pellet lot number, an insertion note, a previous testosterone dose, and a previous estradiol dose.

28. The method according to claim 27, further comprising automatically displaying at least one of the previous estradiol dose and the previous testosterone dose on the display screen, wherein the previous estradiol dose and the previous testosterone dose are based on a last full dosage, the last full dosage being different from at least one previous effective dosage.

29. The method according to claim 27, wherein tracking the pellet insertion location and the pellet insertion side is based on historical insertion information including at least one of a hip location, an abdominal location, a left side, and a right side;

and

wherein, based on the historical insertion information, the pellet insertion location and the pellet insertion side are automatically suggested by the processor.

30. The method according to claim 27, wherein tracking the pellet lot number comprises entering a corresponding lot number into at least one lot number field provided on the display screen of the input device.

31. The method according to claim 22, further comprising:

ordering, by the processor, a plurality of pellet sizes from largest to smallest;

subtracting, by the processor, a largest of the plurality of pellet sizes from the effective dosage; and

if a result of the subtraction is greater than zero, assigning the largest of the plurality of pellet sizes as the estradiol pellet size insertion or the testosterone pellet size insertion;

if a result of the subtraction is less than zero, subtracting a next smallest one of the plurality of pellet sizes from the effective dosage until the result is greater than zero; and

calculating an absolute value of the result of the subtraction that is less than zero and an absolute value of the result of the subtraction that is greater than zero; and

assigning, by the processor, one of the plurality of pellet sizes as the estradiol pellet size insertion or the testosterone pellet size insertion corresponding to the result having a lesser absolute value.

32. The method according to claim 22, further comprising incorporating, by the processor at least one return visit associated with the patient to determine at least one of the effective estradiol dosage and the effective testosterone dosage.

33. The method according to claim 22, further comprising providing a comprehensive toolkit on the input device, the comprehensive toolkit kit comprising at least one of an ancillary support function, a patient consult request, a patient consult response, an article, a video, a form, news, an update, a product purchase order, a financial report, and an assistant assignment related to the dosage and patient treatment life-cycle.

34. The method according to claim 22, further comprising:

tracking, using the processor, a profitability metric for the patient; and

generating a report corresponding to the profitability metric over time.