Radioactive liquid embolic
First Claim
Patent Images
1. A polymeric composition comprising:
- a biocompatible polymer comprising a reaction product of;
a first monomer including a polymerizable moiety having a linkage to a visualization agent having at least one aromatic ring, wherein the at least one aromatic ring includes at least one iodine atom, wherein at least one of the at least one iodine atom is a radioactive isotope, and wherein the first monomer is 2,4,6-triiodophenyl 5-(2-(2-(acryloyloxy)acetoxy)acetoxy)-2-methyl-4-oxohexanoate,and a second monomer including a polymerizable moiety and at least one hydroxyl group; and
a non-physiological solution;
wherein the biocompatible polymer is soluble in the non-physiological solution and insoluble in a physiological solution.
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Abstract
Liquid embolic preparations and medical treatment methods of using those preparations are described. In some embodiments, the preparations or solutions can transition from a liquid to a solid for use in the embolization. The preparations can include biocompatible polymers with covalently bound radioactive iodine isotopes.
184 Citations
20 Claims
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1. A polymeric composition comprising:
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a biocompatible polymer comprising a reaction product of; a first monomer including a polymerizable moiety having a linkage to a visualization agent having at least one aromatic ring, wherein the at least one aromatic ring includes at least one iodine atom, wherein at least one of the at least one iodine atom is a radioactive isotope, and wherein the first monomer is 2,4,6-triiodophenyl 5-(2-(2-(acryloyloxy)acetoxy)acetoxy)-2-methyl-4-oxohexanoate, and a second monomer including a polymerizable moiety and at least one hydroxyl group; and a non-physiological solution; wherein the biocompatible polymer is soluble in the non-physiological solution and insoluble in a physiological solution. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 19)
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10. A polymeric composition comprising:
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biocompatible polymer particles, wherein the polymer particles include a reaction product of; a first monomer including a polymerizable moiety having a linkage to a visualization agent having at least one aromatic ring, wherein the at least one aromatic ring includes at least one iodine atom, wherein at least one of the at least one iodine atom is a radioactive isotope, and wherein the first monomer is 2,4,6-triiodophenyl 5-(2-(2-(acryloyloxy)acetoxy)acetoxy)-2-methyl-4-oxohexanoate, and a second monomer including a polymerizable moiety. - View Dependent Claims (11, 12, 13, 14, 15, 16, 17, 18, 20)
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Specification