Systems to promote healing at a site of a medical device
First Claim
1. A method of delivering a hydrogel system to an in vivo site of an implanted medical device in a subject, the method comprising:
- (a) implanting a medical device in an in vivo site of a subject;
(b) delivering a hydrogel into the in vivo site of the implanted medical device by injection, the hydrogel comprising;
(1) a network of microgel particles, each microgel particle having a median diameter of about 10 micrometers (μ
m) to about 500 μ
m and comprising;
(i) annealing components, wherein an annealing component is configured to bond to an adjacent annealing component; and
(ii) a backbone polymer; and
(2) a plurality of interconnected pores, the plurality of interconnected pores having a median size of at least 10 μ
m;
(c) delivering an annealing agent to the in vivo site of the implanted medical device; and
(d) exposing the hydrogel and the annealing agent to light causing the annealing components to bond to adjacent annealing components to stabilize the network of microgel particles comprising the plurality of interconnected pores, the stabilized hydrogel comprising;
(1) an inner surface molded to a shape of the implanted medical device;
(2) an outer surface molded to a shape of the in vivo site of the implanted medical device in the subject; and
(3) a compressive modulus of between 1,500 and 200,000 Pascal (Pa).
1 Assignment
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Accused Products
Abstract
Disclosed herein are systems for promoting healing of a wound or surgical incision at a medical device site (e.g., implanted medical device) in a subject, by administering a microporous gel to the medical implant site. Also disclosed are systems for the treatment and prevention of infection at a medical implant site in a subject, by administering a microporous gel to the medical implant site. The microporous gel may be fluidic during application and annealed or crosslinked after application. The microporous gels may contain various therapeutic agents, including antibiotics and analgesics, throughout the gel.
81 Citations
19 Claims
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1. A method of delivering a hydrogel system to an in vivo site of an implanted medical device in a subject, the method comprising:
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(a) implanting a medical device in an in vivo site of a subject; (b) delivering a hydrogel into the in vivo site of the implanted medical device by injection, the hydrogel comprising; (1) a network of microgel particles, each microgel particle having a median diameter of about 10 micrometers (μ
m) to about 500 μ
m and comprising;(i) annealing components, wherein an annealing component is configured to bond to an adjacent annealing component; and (ii) a backbone polymer; and (2) a plurality of interconnected pores, the plurality of interconnected pores having a median size of at least 10 μ
m;(c) delivering an annealing agent to the in vivo site of the implanted medical device; and (d) exposing the hydrogel and the annealing agent to light causing the annealing components to bond to adjacent annealing components to stabilize the network of microgel particles comprising the plurality of interconnected pores, the stabilized hydrogel comprising; (1) an inner surface molded to a shape of the implanted medical device; (2) an outer surface molded to a shape of the in vivo site of the implanted medical device in the subject; and (3) a compressive modulus of between 1,500 and 200,000 Pascal (Pa). - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19)
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Specification