Passivation, pH protective or lubricity coating for pharmaceutical package, coating process and apparatus
First Claim
1. A vessel comprising:
- a thermoplastic wall having an interior surface enclosing a lumen;
a fluid contained in the lumen having a pH greater than 5 disposed in the lumen;
a barrier coating or layer of SiOx, in which x is between 1.5 and 2.9, the barrier coating or layer applied by PECVD, positioned between the interior surface of the thermoplastic wall and the fluid, and supported by the thermoplastic wall, the barrier coating or layer having the characteristic of being subject to being measurably diminished in barrier improvement factor in less than six months as a result of attack by the fluid; and
a passivation layer or pH protective coating of SiOxCy, in which x is between 0.5 and 2.4 and y is between 0.6 and 3, the passivation layer or pH protective coating applied by PECVD, positioned between the barrier coating or layer and the fluid, and supported by the thermoplastic wall, the passivation layer or pH protective coating being effective to keep the barrier coating or layer at least substantially undissolved as a result of attack by the fluid for a period of at least six months.
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Accused Products
Abstract
A method for providing a passivation layer or pH protective coating on a substrate surface by PECVD is provided, the method comprising generating a plasma from a gaseous reactant comprising polymerizing gases. The lubricity, passivation, pH protective, hydrophobicity, and/or barrier properties of the passivation layer or pH protective coating are set by setting the ratio of the O2 to the organosilicon precursor in the precursor feed, and/or by setting the electric power used for generating the plasma. In particular, a passivation layer or pH protective coating made by the method is provided. Pharmaceutical packages coated by the method and the use of such packages protecting composition contained in the vessel against mechanical and/or chemical effects of the surface of the package without a passivation layer or pH protective coating material are also provided.
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Citations
13 Claims
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1. A vessel comprising:
- a thermoplastic wall having an interior surface enclosing a lumen;
a fluid contained in the lumen having a pH greater than 5 disposed in the lumen;
a barrier coating or layer of SiOx, in which x is between 1.5 and 2.9, the barrier coating or layer applied by PECVD, positioned between the interior surface of the thermoplastic wall and the fluid, and supported by the thermoplastic wall, the barrier coating or layer having the characteristic of being subject to being measurably diminished in barrier improvement factor in less than six months as a result of attack by the fluid; and
a passivation layer or pH protective coating of SiOxCy, in which x is between 0.5 and 2.4 and y is between 0.6 and 3, the passivation layer or pH protective coating applied by PECVD, positioned between the barrier coating or layer and the fluid, and supported by the thermoplastic wall, the passivation layer or pH protective coating being effective to keep the barrier coating or layer at least substantially undissolved as a result of attack by the fluid for a period of at least six months. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13)
- a thermoplastic wall having an interior surface enclosing a lumen;
Specification
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- Resources
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Current AssigneeSiO2 Medical products Inc.
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Original AssigneeSiO2 Medical products Inc.
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InventorsFelts, John T., Fisk, Thomas E., Abrams, Robert S., Ferguson, John, Freedman, Jonathan R., Pangborn, Robert J., Sagona, Peter J., Weikart, Christopher
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Primary Examiner(s)Miggins, Michael C
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Application NumberUS16/226,463Publication NumberTime in Patent Office440 DaysField of SearchUS Class CurrentCPC Class CodesA61J 1/05 for collecting, storing or ...A61M 2005/3109 Caps sealing the needle bor...A61M 2005/3131 specially adapted for impro...A61M 5/3129 Syringe barrels A61M5/3205 ...B65D 25/04 PartitionsB65D 25/14 Linings or internal coating...C23C 16/045 Coating cavities or hollow ...C23C 16/30 Deposition of compounds, mi...C23C 16/36 CarbonitridesC23C 16/401 containing siliconC23C 16/507 using external electrodes, ...
