Crystal forms and production methods thereof
First Claim
Patent Images
1. A crystalline form of (R)-(+)-amisulpride characterized by a powder x-ray diffraction pattern comprising peaks, in terms of 2-theta, at 7.0±
- 0.2°
, 9.7±
0.2°
, and 15.4±
0.2°
, wherein the crystalline form of (R)-(+)-amisulpride has a chiral purity greater than about 95%.
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Abstract
The various aspects present inventions provide various crystalline forms of (S)-(−)-amisulpride, (R)-(+)-amisulpride, and solvates thereof and methods of making same. In various aspects, the inventions also provide methods of resolving racemic amisulpride.
60 Citations
42 Claims
-
1. A crystalline form of (R)-(+)-amisulpride characterized by a powder x-ray diffraction pattern comprising peaks, in terms of 2-theta, at 7.0±
- 0.2°
, 9.7±
0.2°
, and 15.4±
0.2°
, wherein the crystalline form of (R)-(+)-amisulpride has a chiral purity greater than about 95%. - View Dependent Claims (2, 3, 4, 5, 6, 35)
- 0.2°
-
7. A crystalline form of (R)-(+)-amisulpride characterized by a powder x-ray diffraction pattern comprising peaks, in terms of 2-theta, at 7.0±
- 0.2°
, 9.7±
0.2°
, and 15.4±
0.2°
, wherein the crystalline form of (R)-(+)-amisulpride has a chemical purity greater than about 95%. - View Dependent Claims (8, 9, 10, 11, 12, 36)
- 0.2°
-
13. A crystalline form of (R)-(+)-amisulpride characterized by a powder x-ray diffraction pattern comprising peaks, in terms of 2-theta, at 7.0±
- 0.2°
, 9.7±
0.2°
, and 15.4±
0.2°
, wherein the crystalline form of (R)-(+)-amisulpride has a polymorph purity greater than about 90%. - View Dependent Claims (14, 15, 16, 37)
- 0.2°
-
17. A crystalline form of (R)-(+)-amisulpride characterized by a powder x-ray diffraction pattern comprising peaks, in terms of 2-theta, at 7.0±
- 0.2°
, 9.7±
0.2°
, and 15.4±
0.2°
, wherein the crystalline form of (R)-(+)-amisulpride has a chiral purity greater than about 97%, a chemical purity greater than about 97%, and a polymorph purity greater than about 90%. - View Dependent Claims (38)
- 0.2°
-
18. A crystalline form of (S)-(−
- )-amisulpride characterized by a powder x-ray diffraction pattern comprising peaks, in terms of 2-theta, at 7.0±
0.2°
, 9.7±
0.2°
, and 15.4±
0.2°
, wherein the crystalline form of (S)-(−
)-amisulpride has a chiral purity greater than about 95%. - View Dependent Claims (19, 20, 21, 22, 23, 39)
- )-amisulpride characterized by a powder x-ray diffraction pattern comprising peaks, in terms of 2-theta, at 7.0±
-
24. A crystalline form of (S)-(−
- )-amisulpride characterized by a powder x-ray diffraction pattern comprising peaks, in terms of 2-theta, at 7.0±
0.2°
, 9.7±
0.2°
, and 15.4±
0.2°
, wherein the crystalline form of (S)-(−
)-amisulpride has a chemical purity greater than about 95%. - View Dependent Claims (25, 26, 27, 28, 29, 40)
- )-amisulpride characterized by a powder x-ray diffraction pattern comprising peaks, in terms of 2-theta, at 7.0±
-
30. A crystalline form of (S)-(−
- )-amisulpride characterized by a powder x-ray diffraction pattern comprising peaks, in terms of 2-theta, at 7.0±
0.2°
, 9.7±
0.2°
, and 15.4±
0.2°
, wherein the crystalline form of (S)-(−
)-amisulpride has a polymorph purity greater than about 90%. - View Dependent Claims (31, 32, 33, 41)
- )-amisulpride characterized by a powder x-ray diffraction pattern comprising peaks, in terms of 2-theta, at 7.0±
-
34. A crystalline form of (S)-(−
- )-amisulpride characterized by a powder x-ray diffraction pattern comprising peaks, in terms of 2-theta, at 7.0±
0.2°
, 9.7±
0.2°
, and 15.4±
0.2°
, wherein the crystalline form of (S)-(−
)-amisulpride has a chiral purity greater than about 97%, a chemical purity greater than about 97%, and a polymorph purity greater than about 90%. - View Dependent Claims (42)
- )-amisulpride characterized by a powder x-ray diffraction pattern comprising peaks, in terms of 2-theta, at 7.0±
Specification