Contact lens product

• US 10,578,889 B2
• Filed: 06/26/2019
• Issued: 03/03/2020
• Est. Priority Date: 02/04/2016
• Status: Active Grant

• Current Assignee: Largan Medical Co., Ltd.
• Original Assignee: Largan Medical Co., Ltd.
• Inventors: Lin, En-Ping, Chen, Wei-Yuan, Teng, Chun-Hung
• Primary Examiner(s): Beatty, Collin X
• Assistant Examiner(s): Gagnon, Grant A
• Application Number:
  US16/452,725
• Publication Number:
  US 20190317339A1
• Time in Patent Office: 251 Days
• Field of Search: 351159
• CPC Class Codes: A61K 38/168 from plants
• CPC Class Codes: A61K 47/14 Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
• CPC Class Codes: A61K 47/22 Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
• CPC Class Codes: A61K 47/32 Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers , poly(meth)acrylates, or polyvinyl pyrrolidone
• CPC Class Codes: A61K 47/34 Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers A61K47/10 takes precedence
• CPC Class Codes: A61K 9/0051 Ocular inserts, ocular implants
• CPC Class Codes: A61K 9/06 Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels composition of ointments, creams or gels A61K47/00
• CPC Class Codes: A61K 9/08 Solutions composition of solutions A61K47/00
• CPC Class Codes: C08L 101/14 the macromolecular compounds being water soluble or water swellable, e.g. aqueous gels
• CPC Class Codes: C08L 33/08 Homopolymers or copolymers of acrylic acid esters
• CPC Class Codes: C08L 33/10 Homopolymers or copolymers of methacrylic acid esters
• CPC Class Codes: C08L 33/26 Homopolymers or copolymers of acrylamide or methacrylamide
• CPC Class Codes: G02B 1/043 Contact lenses
• CPC Class Codes: G02C 2202/24 Myopia progression prevention
• CPC Class Codes: G02C 7/04 Contact lenses for the eyes disinfection or sterilisation of contact lenses A61L12/00
• CPC Class Codes: G02C 7/049 Contact lenses having special fitting or structural features achieved by special materials or material structures
• CPC Class Codes: G02C 7/104 having spectral characteristics for purposes other than sun-protection

Abstract

A contact lens product includes a contact lens and a buffer solution. The contact lens is immersed in the buffer solution, and the buffer solution includes a cycloplegic agent.

Claims

1. A contact lens product, comprising:

a contact lens; and

a buffer solution, wherein the contact lens is immersed in the buffer solution, and the buffer solution comprises a cycloplegic agent;

wherein a weight percentage concentration of the cycloplegic agent in the buffer solution is ConA, a visible light absorption rate of the contact lens is Avi, a blue light absorption rate of the contact lens is Abl, and the following conditions are satisfied;

0.01%≤

ConA;

0%<

Avi≤

45%; and

10%≤

Abl≤

70%.

2. The contact lens product of claim 1, wherein the weight percentage concentration of the cycloplegic agent in the buffer solution is ConA, and the following condition is satisfied:

0.01%≤

ConA<

0.5%.

3. The contact lens product of claim 1, wherein the visible light absorption rate of the contact lens is Avi, and the following condition is satisfied:

15%≤

Avi≤

25.5%.

4. The contact lens product of claim 3, wherein a composition for manufacturing the contact lens comprises at least one visible light absorbing agent, and the visible light absorbing agent is 1,4-bis[4-(2-methacryloxyethyl)phenylamino]anthraquinone or 1,4-bis[(2-methacryloxyethyl)amino]-9,10-anthraquinone.

5. The contact lens product of claim 1, wherein the contact lens is made of a silicone hydrogel.

6. The contact lens product of claim 5, wherein a composition for manufacturing the silicone hydrogel comprises at least two monomers, the monomer is 2-hydroxyethyl methacrylate, 3-methacryloyloxypropyltris(trimethylsilyloxy)silane, N-vinyl-2-pyrrolidinone, N,N-dimethyl acrylamide, methacrylic acid, methyl methacrylate, 3-(3-methacryloxy-2-hydroxypropoxy)propylbis(trimethylsiloxy)methylsilane or (3-acryloxy-2-hydroxypropoxypropyl)terminated polydimethylsiloxane.

7. The contact lens product of claim 1, wherein the contact lens is made of a hydrogel.

8. The contact lens product of claim 7, wherein a composition for manufacturing the hydrogel comprises at least two monomers, the monomer is 2-hydroxyethyl methacrylate, methacrylic acid, glycerol monomethacrylate or N-vinyl-2-pyrrolidinone.

9. The contact lens product of claim 1, wherein a composition for manufacturing the contact lens comprises at least one short-wavelength light absorbing agent, the blue light absorption rate of the contact lens is Abl, and the following condition is satisfied:

40%≤

Abl≤

60%.

10. The contact lens product of claim 9, wherein the short-wavelength light absorbing agent is 4-(phenyldiazenyl) phenyl methacrylate or reactive yellow 15.

11. The contact lens product of claim 10, wherein the ultraviolet light absorption rate of the contact lens is Auv, and the following condition is satisfied:

72.7%≤

Auv≤

96.8%.

12. The contact lens product of claim 11, wherein the short-wavelength light absorbing agent is 2-(2′

-hydroxy-5′

-methacryloxyethylphenyl)-2H-benzotriazole, 2-(4-benzoyl-3-hydroxyphenoxy)ethyl acrylate, 3-(3-(tert-butyl)-4-hydroxy-5-(5-methoxy-2H-benzo[d][1,2,3]triazol-2-yl)phenoxy) propyl methacrylate, 1,3-bis(4-benzoyl-3-hydroxyphenoxy)-2-propyl methacrylate, 1,3-bis(4-benzoyl-3-hydroxyphenoxy)-2-propanyl acrylate or N-(4-hydroxy-3-(5-methoxy-2H-benzo[d][1,2,3]triazol-2-yl)phenyl)methacrylamide.

13. The contact lens product of claim 1, wherein the contact lens comprises:

a central region; and

at least one annular region surrounding the central region, wherein a diopter of the annular region is different from a diopter of the central region, the annular region is a first annular region, the diopter of the central region of the contact lens is PowC, a maximum diopter of the first annular region of the contact lens is PowP1, and the following condition is satisfied;

2.25 D≤

PowP1−

PowC.

14. The contact lens product of claim 13, wherein the diopter of the central region of the contact lens is PowC, the maximum diopter of the first annular region of the contact lens is PowP1, and the following condition is satisfied:

2.25 D≤

PowP1−

PowC≤

12 D.

15. The contact lens product of claim 14, wherein a diameter of the central region of the contact lens is DiC, and the following condition is satisfied:

4 mm≤

DiC≤

8 mm.

16. The contact lens product of claim 15, wherein an outer diameter of the first annular region of the contact lens is DiP1, and the following condition is satisfied:

6 mm≤

DiP1≤

16 mm.

17. The contact lens product of claim 16, wherein the diameter of the central region of the contact lens is DiC, the outer diameter of the first annular region of the contact lens is DiP1, and the following condition is satisfied:

0.27≤

DiC/DiP1≤

0.64.