Clot capture systems and associated methods

• US 10,582,939 B2
• Filed: 07/07/2016
• Issued: 03/10/2020
• Est. Priority Date: 07/22/2008
• Status: Active Grant

• Current Assignee: Neuravi Limited (Johnson & Johnson)
• Original Assignee: Neuravi Limited (Johnson & Johnson)
• Inventors: Brady, Eamon, Vale, David, Gilvarry, Michael, Razavi, Mahmood, O'Shaughnessy, John
• Primary Examiner(s): Yabut, Diane D
• Application Number:
  US15/204,537
• Publication Number:
  US 20160317168A1
• Time in Patent Office: 1,342 Days
• CPC Class Codes: A61B 17/221 Gripping devices in the form of loops or baskets for gripping calculi or similar types of obstructions surgical snare instruments A61B17/32056
• CPC Class Codes: A61B 2017/2212 having a closed distal end, e.g. a loop
• CPC Class Codes: A61F 2/013 Distal protection devices, i.e. devices placed distally in combination with another endovascular procedure, e.g. angioplasty or stenting
• CPC Class Codes: A61F 2230/0006 circular
• CPC Class Codes: A61F 2230/0008 elliptical or oval
• CPC Class Codes: A61F 2230/001 Figure-8-shaped, e.g. hourglass-shaped
• CPC Class Codes: A61F 2230/005 Rosette-shaped, e.g. star-shaped
• CPC Class Codes: A61F 2230/0058 X-shaped

Abstract

A clot capture system for disengaging a clot from a vessel wall and removing the clot from the vessel. The system may include a clot capture device for placement on a distal side of a clot. The clot capture device may have a retracted delivery configuration and an expanded deployed configuration. The clot removal device may have a proximal support frame, and a distal fiber net. The support frame may have a retracted delivery configuration and an expanded deployed configuration. The proximal support frame in the expanded configuration may define a proximal inlet mouth for engaging a clot and a net for confining the clot. An elongate member may facilitate capture and/or withdrawal of a clot from a vessel.

Claims

1. A system, including:

a tubular member defining a lumen extending therethrough;

a microcatheter slidably disposed in the lumen;

an expandable framework positioned at a distal end of the tubular member, the expandable framework defining a lumen in communication with the lumen of the tubular member and expandable between a collapsed state and an expanded state,

wherein in the expanded state, the expandable framework is advanced distal of a distal end of the microcatheter and then caused to expand from the collapsed state to the expanded state projecting radially outwardly of the tubular member with an open distalmost end defining a maximum radial size of the expandable framework,

wherein in the collapsed state, a proximalmost end of the expandable framework and the tubular member have a common radial dimension less than the maximum radial size of the expandable framework;

an expandable porous body configured to capture a clot, the expandable porous body being longitudinally moveable distally of the tubular member and the expandable framework; and

a gap disposed between the expandable framework and the expandable porous body, the gap sized to receive the clot.

2. The system of claim 1, wherein the expandable framework is monolithically formed with the tubular member.

3. The system of claim 1, wherein, in the collapsed state, a length of the expandable framework between the proximalmost end and the distalmost end and the tubular member have a common radial dimension.

4. The system of claim 1, wherein the expandable framework is a porous strut framework and includes a plurality of closed cells.

5. The system of claim 1, wherein the tubular member includes a non-porous circumferential wall.

6. The system of claim 1, further comprising an actuating element connected to the expandable framework for actuating the expandable framework between collapsed and expanded states, the actuating element running within the tubular member to the expandable framework, and wherein retraction of the actuating element applies a compressive force to the distalmost end of the expandable framework.

7. The system of claim 1, wherein the expandable porous body is tapered such that a proximal end of the expandable porous body has a first radial size and the distal end of the expandable porous body has a second radial size smaller than the first radial size.

8. The system of claim 1, wherein the expandable porous body includes an open proximal mouth facing the expandable framework.

9. A system, comprising:

a tubular member defining a lumen extending therethrough;

a microcatheter slidably disposed in the lumen;

an expandable framework positioned distally of a distal end of the tubular member, the expandable framework defining a lumen in communication with the lumen of the tubular member and having an open distal end, and self-expandable between a collapsed state and a expanded state,

wherein in the collapsed state, the expandable framework and the tubular member have a common radial dimension less than a maximum radial size of the expandable framework, and

wherein in the expanded state, the expandable framework is advanced distal of a distal end of the microcatheter and then caused to expand from the collapsed state to the expanded state projecting radially outwardly of the tubular member with a distalmost end having the maximum radial size of the expandable framework;

an expandable capture structure configured to capture a clot, the expandable capture structure being longitudinally moveable with respect to the tubular member from a collapsed delivery state to a deployed expanded state distally beyond the expandable framework, wherein the capture structure is porous and includes an open proximal mouth coupled to a longitudinally extending member moveably received within the lumen of the tubular member; and

a gap disposed between the expandable framework and the expandable capture structure, the gap sized to receive the clot.

10. The system of claim 9, wherein the tubular member includes a non-porous circumferential wall.

11. The system of claim 9, wherein the expandable capture structure is tapered such that a proximal end of the expandable capture structure has a first radial size and a distal end of the expandable capture structure has a second radial size smaller than the first radial size.

12. The system of claim 11, further comprising an actuating element connected to the expandable framework for causing the expandable framework to expand between collapsed and expanded states, the actuating element comprising an elongate member running within the tubular member to the expandable framework, and wherein retraction of the actuating element applies a compressive force to the distalmost end of the expandable framework.

13. The system of claim 9, wherein a proximal end of the expandable framework is longitudinally fixed relative to a distal end of the tubular member.

14. The system of claim 9, wherein the open proximal mouth faces the expandable framework.

15. A method, including:

slidably positioning a tubular member over a microcatheter;

expanding the tubular member from a collapsed state to an expanded state by;

distally advancing an expandable framework located at a distal end of the tubular member distal of a distal end of a microcatheter; and

subsequently projecting radially the tubular member with an open distalmost end defining a maximum radial size of the expandable framework,

wherein the expandable framework defines a lumen in communication with a lumen of the tubular member, and wherein, in the collapsed state, a proximalmost end of the expandable framework and the tubular member have a common radial dimension less than the maximum radial size of the expandable framework;

extending an expandable porous body distally of the tubular member to expand the expandable porous body from a collapsed delivery state to a deployed expanded state, the expandable porous body having a closed distal end and an open proximal mouth;

positioning a gap between the expandable framework and the expandable porous body, the gap sized for capturing an obstruction; and

receiving the obstruction in the gap via the expandable framework and the expandable porous body.

16. The method of claim 15, further including actuating the expandable framework by proximally retracting an actuating element coupled to the expandable framework;

and

applying a compressive force to the distalmost end of the expandable framework.

17. The method of claim 16, further including moving a longitudinally extending member coupled to the expandable porous body with respect to the lumen of the tubular member;

wherein the open proximal mouth faces the expandable framework and the longitudinally extending member is coupled to the open proximal mouth.

18. The method of claim 16, wherein, in the collapsed state, a length of the expandable framework between the proximalmost end and the distalmost end and the tubular member have a common radial dimension.

19. The method of claim 16, further including dislodging the obstruction via the expandable framework.