Hydrophilic polymer coatings with durable lubricity and compositions and methods thereof

• US 10,583,034 B2
• Filed: 09/27/2019
• Issued: 03/10/2020
• Est. Priority Date: 10/14/2016
• Status: Active Grant

• Current Assignee: Hydroglyde Coatings LLC
• Original Assignee: Hydroglyde Coatings LLC
• Inventors: Chin, Stacy Lee, Cooper, Benjamin Goldman, Xiao, Ruiqing, Grinstaff, Mark W.
• Primary Examiner(s): Mulcahy, Peter D.
• Application Number:
  US16/585,592
• Publication Number:
  US 20200038233A1
• Time in Patent Office: 165 Days
• CPC Class Codes: A61F 6/04 Condoms, sheaths or the like , e.g. combined with devices protecting against contagion
• CPC Class Codes: B29C 41/22 Making multilayered or multicoloured articles
• CPC Class Codes: B32B 2307/728 Hydrophilic
• CPC Class Codes: B32B 27/26 using curing agents
• CPC Class Codes: B32B 27/28 comprising synthetic resins not wholly covered by any one of the sub-groups B32B27/30 - B32B27/42
• CPC Class Codes: B32B 27/285 comprising polyethers
• CPC Class Codes: B32B 27/30 comprising vinyl (co)polymers; comprising acrylic (co)polymers
• CPC Class Codes: B32B 27/302 comprising aromatic vinyl (co)polymers, e.g. styrenic (co)polymers
• CPC Class Codes: B32B 27/306 comprising vinyl acetate or vinyl alcohol (co)polymers
• CPC Class Codes: B32B 27/36 comprising polyesters
• CPC Class Codes: C08J 2300/26 Elastomers
• CPC Class Codes: C08J 2307/00 Characterised by the use of natural rubber
• CPC Class Codes: C08J 2307/02 Latex
• CPC Class Codes: C08J 2347/00 Characterised by the use of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, at least one having two or more carbon-to-carbon double bonds; Derivatives of such polymers C08J2345/00 takes precedence; of conjugated diene rubbers C08J2309/00 - C08J2321/00
• CPC Class Codes: C08J 2407/02 Latex
• CPC Class Codes: C08J 2409/02 Copolymers with acrylonitrile
• CPC Class Codes: C08J 7/042 with two or more layers, where at least one layer of a composition contains a polymer binder
• CPC Class Codes: C08J 7/043 Improving the adhesiveness of the coatings per se, e.g. forming primers adhesives in the form of films or foils characterised by the primer layers between the polymer carriers and the adhesives C09J7/50
• CPC Class Codes: C08J 7/056 Forming hydrophilic coatings
• CPC Class Codes: C08L 11/02 Latex
• CPC Class Codes: C08L 29/04 : Polyvinyl alcohol; Partially hydrolysed homopolymers or copolymers of esters of unsaturated alcohols with saturated carboxylic acids
• CPC Class Codes: C08L 7/02 : Latex
• CPC Class Codes: C08L 9/08 : Latex
• CPC Class Codes: C09D 107/02 : Latex
• CPC Class Codes: C09D 109/08 : Latex

Abstract

The invention provides a novel hydrophilic polymer and latex polymer blend coating formulation and compositions thereof, and their use on various devices (e.g., prophylactic and medical devices) to form hydrophilic and flexible coatings with durable lubricity.

Claims

1. An aqueous composition, comprising:

a hydrophilic polymer selected from poly(vinyl pyrrolidone) (PVP), poly(ethylene glycol) (PEG), and poly(vinyl alcohol) (PVA);

a suspension of latex polymer microparticles; and

one or more of vulcanizing or accelerating agents, wherein

the hydrophilic polymer has a mean molecular weight in the range from about 100 kDa to about 10,000 kDa and is present in the composition at a concentration from about 2 w/v % to about 7 w/v %;

the latex polymer microparticles are present in the composition at a concentration from about 35 w/v % to about 65 w/v %;

a viscosity in the range from about 10 cP to about 10¹⁰ cP; and

the weight ratio of the hydrophilic polymer to the latex polymer microparticles is in the range from about 1;

1 to about 1;

3.

2. The composition of claim 1, being an evenly mixed and stable suspension.

5. The composition of claim 1, wherein the hydrophilic polymer comprises PVP.

6. The composition of claim 5, wherein the hydrophilic polymer comprises a second hydrophilic polymer.

11. The composition of claim 1, further comprising one or more of antimicrobials, antivirals, antifungals, vitamins, colors, or antibiotics.

12. The composition of claim 1, wherein the latex polymer is natural latex.

13. The composition of claim 1, wherein the latex polymer is synthetic latex.

14. The composition of claim 1, wherein the synthetic rubber latex is synthetized from isoprene, nitrile, butadiene, styrene-butadiene, chloroprene, isobutylene, or co-polymers thereof.

15. A cured material formed by heating the composition of claim 1 for a time sufficient to form interpenetrating polymer networks of crosslinked hydrophilic polymer and latex polymer.

16. The cured material of claim 15, wherein the material is a coating forming a surface of a product.

17. The cured material of claim 16, wherein the product is selected from the group consisting:

a condom, a sex toy, a surgical device, a medical implant, or a glove.

18. The cured material of claim 17, wherein the cured material is less cytotoxic compared to non-coated latex materials alone.

3. A composition formed by mixing:

a first aqueous solution of a hydrophilic polymer selected from poly(vinyl pyrrolidone) (PVP), poly(ethylene glycol) (PEG), and poly(vinyl alcohol) (PVA) with a concentration in the range from about 1 w/v % to about 20 w/v %; and

a second aqueous suspension of latex polymer microparticles with a concentration in the range from about 35 w/v % to about 70 w/v %; and

wherein

the hydrophilic polymer has a mean molecular weight in the range from about 100 kDa to about 10,000 kDa; and

the volume ratio of the first aqueous solution to the second aqueous suspension is in the range from about 1;

1 to about 1;

3, wherein

the hydrophilic polymer is present in the composition at a concentration from about 2 w/v % to about 7 w/v %;

the latex polymer microparticles are present in the composition at a concentration from about 35 w/v % to about 65 w/v %.

4. The composition of claim 3, having the hydrophilic polymer at a concentration from about 2 w/v % to about 7 w/v % and the latex polymer microparticles at a concentration from about 20 w/v % to about 60 w/v %.

7. The composition of claim 3, further comprising one or more of vulcanizing agents or accelerating agents.

8. The composition of claim 7, wherein the one or more of vulcanizing agents or the one or more of accelerating agents are present in the first aqueous solution a hydrophilic polymer.

9. The composition of claim 7, wherein the one or more of vulcanizing agents or the one or more of accelerating agents are present in the second aqueous suspension of latex polymer microparticles.

10. The composition of claim 9, wherein the vulcanizing agents are selected from the group consisting of:

diisopropyl xanthogen polysulfide, sulfur, and ammonia and the accelerating agents are selected from the group consisting of;

zinc-N-diethyl-dithio-carbomate, zinc-N-dibutyl-dithio-carbomate, and ammonia.