Compounds, compositions and methods for making the same

• US 10,583,119 B2
• Filed: 11/08/2016
• Issued: 03/10/2020
• Est. Priority Date: 04/21/2008
• Status: Active Grant

• Current Assignee: Signum Biosciences, Inc.
• Original Assignee: Signum Biosciences, Inc.
• Inventors: Vafai, Scott, Voronkov, Michael, Stock, Maxwell, Stock, Jeffry B., Lee, Seung-Yub, Li, Zhu, Gu, Haoming
• Primary Examiner(s): Pihonak, Sarah
• Application Number:
  US15/346,636
• Publication Number:
  US 20170266161A1
• Time in Patent Office: 1,218 Days
• CPC Class Codes: A61K 31/405 Indole-alkanecarboxylic acids; Derivatives thereof, e.g. tryptophan, indomethacin
• CPC Class Codes: A61P 25/00 Drugs for disorders of the nervous system
• CPC Class Codes: A61P 25/16 Anti-Parkinson drugs
• CPC Class Codes: A61P 25/28 for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
• CPC Class Codes: A61P 25/30 for treating abuse or dependence
• CPC Class Codes: A61P 3/00 Drugs for disorders of the metabolism of the blood or the extracellular fluid A61P7/00
• CPC Class Codes: A61P 3/10 for hyperglycaemia, e.g. antidiabetics
• CPC Class Codes: A61P 43/00 Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
• CPC Class Codes: A61P 5/50 for increasing or potentiating the activity of insulin

Abstract

The present invention provides compounds and/or compositions that modulate PP2A methylation and/or activity and methods for preparing the same, which are useful for modulating the demethylation of PP2A, modulating the methylation of PP2A and/or modulating the activity of PP2A.

Claims

1. A compound represented by the formula:

2. The compound of claim 1, wherein n is 0.

4. The compound of claim 1, wherein R′

is methyl.

5. The compound of claim 1, wherein R′

is a substituted C₁-C₆ alkyl group.

6. The compound of claim 5, wherein the C₁-C₆ alkyl group is substituted with a —

COOH group.

7. The compound of claim 6, wherein E is —

C(O)(CH₂)2C(O)OH.

3. A compound represented by the formula:

8. A compound selected from the group consisting of:

9. The compound of claim 8, wherein the compound is:

10. The compound of claim 8, wherein the compound is:

11. The compound of claim 8, wherein the compound is:

12. A compound represented by the formula:

13. The compound of claim 12, wherein X is NH.

14. The compound of claim 13, wherein Z is

15. The compound of claim 14, wherein n is 0.

16. The compound of claim 14, wherein W is an unsubstituted, uninterrupted, linear, saturated alkyl having between 10 and 25 carbons.

17. The compound of claim 16, wherein W has 18 carbons.

18. The compound of claim 16, wherein W has 19 carbons.

19. The compound of claim 14, wherein Y is hydrogen.

20. The compound of claim 19, wherein E is —

C(O)R′

.

21. The compound of claim 20, wherein R′

is methyl.