Pharmaceutical formulations compromising nitrocatechol derivatives and methods of making thereof
First Claim
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1. A method of treating Parkinson'"'"'s disease, parkinsonian disorders, or restless leg syndrome, said method comprising administering a composition comprising granules comprising 2,5-dichloro-3-(5-(3,4-dihydroxy-5-nitrophenyl)-1,2,4-oxadiazol-3-yl)-4,6-dimethylpyridine 1-oxide to a patient, wherein the composition has a bulk density greater than 0.2 g/mL.
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Abstract
The present disclosure relates to compositions and pharmaceutical formulations comprising at least one active pharmaceutical ingredient chosen from nitrocatechol derivatives of formula I as defined herein and salts, esters, hydrates, solvates and derivatives thereof and methods of making said compositions and pharmaceutical formulations.
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24 Claims
- 1. A method of treating Parkinson'"'"'s disease, parkinsonian disorders, or restless leg syndrome, said method comprising administering a composition comprising granules comprising 2,5-dichloro-3-(5-(3,4-dihydroxy-5-nitrophenyl)-1,2,4-oxadiazol-3-yl)-4,6-dimethylpyridine 1-oxide to a patient, wherein the composition has a bulk density greater than 0.2 g/mL.
- 8. A method of treating Parkinson'"'"'s disease, parkinsonian disorders, or restless leg syndrome, the method comprising administering a pharmaceutical formulation comprising a composition comprising granules comprising 2,5-dichloro-3-(5-(3,4-dihydroxy-5-nitrophenyl)-1,2,4-oxadiazol-3-yl)-4,6-dimethylpyridine 1-oxide to a patient, wherein the composition has a bulk density greater than 0.2 g/mL.
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