Method and system for directing a localized biological response to an implant
First Claim
1. A method, comprising:
- delivering a first tissue response modifier from a first patch placed on a surface of a mammalian body, the first tissue response modifier delivered such that the first tissue response modifier does not reach systemic levels in the mammalian body, the first tissue response modifier configured to, at least one of, (1) minimize a first response of the mammalian body to an implantation of an implant or (2) enhance a second response of the mammalian body to the implantation of the implant;
placing a second patch on the surface of the mammalian body over the implant after the first patch is placed on the surface of the mammalian body;
receiving, from the implant and at the second patch, a signal associated with an analyte, the implant having a first sensitivity to the analyte before a foreign body response of the mammalian body and a second sensitivity less than the first sensitivity after the foreign body response of the mammalian body; and
delivering a second tissue response modifier from the second patch and through an epidermis of the mammalian body to reduce or eliminate the foreign body response of the mammalian body, the second tissue response modifier delivered such that the second tissue response modifier does not reach systemic levels in the mammalian body.
2 Assignments
0 Petitions
Accused Products
Abstract
The invention provides methods for directing a localized biological response of a mammalian body to an implant disposed within the body. In one embodiment, a delivery system is positioned outside the body and adjacent to the implant within the body. The delivery system comprises a first tissue response modifier effective for directing a localized biological response of the body to the implant. The tissue response modifier is nonsurgically delivered from the delivery system into the body in a quantity effective to direct the localized biological response of the body to the implant. The invention also provides an implant system for long-term use comprising an implant and nonsurgical means for delivering a tissue response modifier through the epidermis of the body, the tissue response modifier effective for directing a localized biological response of the body to the implant.
170 Citations
22 Claims
-
1. A method, comprising:
-
delivering a first tissue response modifier from a first patch placed on a surface of a mammalian body, the first tissue response modifier delivered such that the first tissue response modifier does not reach systemic levels in the mammalian body, the first tissue response modifier configured to, at least one of, (1) minimize a first response of the mammalian body to an implantation of an implant or (2) enhance a second response of the mammalian body to the implantation of the implant; placing a second patch on the surface of the mammalian body over the implant after the first patch is placed on the surface of the mammalian body; receiving, from the implant and at the second patch, a signal associated with an analyte, the implant having a first sensitivity to the analyte before a foreign body response of the mammalian body and a second sensitivity less than the first sensitivity after the foreign body response of the mammalian body; and delivering a second tissue response modifier from the second patch and through an epidermis of the mammalian body to reduce or eliminate the foreign body response of the mammalian body, the second tissue response modifier delivered such that the second tissue response modifier does not reach systemic levels in the mammalian body. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11)
-
-
12. A method, comprising:
-
implanting an implant within a mammalian body, the implant configured to measure an analyte of the mammalian body, the implant having a first sensitivity to the analyte before a foreign body response of the mammalian body and a second sensitivity less than the first sensitivity after the foreign body response of the mammalian body; placing a first patch on a surface of the mammalian body over the implant; receiving, from the implant and at the first patch, a signal associated with the analyte; delivering, from the first patch, a first tissue response modifier through an epidermis of the mammalian body to reduce or eliminate the foreign body response of the mammalian body, the first tissue response modifier delivered such that the first tissue response modifier does not reach systemic levels in the mammalian body; placing a second patch on the mammalian body after the first patch is placed on the surface of the mammalian body; receiving, from the implant and at the second patch, the signal associated with the analyte; and delivering, from the second patch, a second tissue response modifier through an epidermis of the mammalian body such that the second tissue response modifier does not reach systemic levels in the mammalian body. - View Dependent Claims (13, 14, 15, 16, 17, 18, 19, 20, 21, 22)
-
Specification