Process for manufacturing an intraocular lens with an embedded mask

• US 10,583,619 B2
• Filed: 01/17/2019
• Issued: 03/10/2020
• Est. Priority Date: 03/14/2013
• Status: Active Grant

• Current Assignee: Acufocus, Inc. (Bausch Health Cos., Inc.)
• Original Assignee: Acufocus, Inc. (Bausch Health Cos., Inc.)
• Inventors: Reboul, Adam C., Benz, Patrick H., Webb, R. Kyle
• Primary Examiner(s): Sultana, Nahida
• Application Number:
  US16/250,392
• Publication Number:
  US 20190315081A1
• Time in Patent Office: 418 Days
• CPC Class Codes: A61F 2/16 Intraocular lenses
• CPC Class Codes: A61F 2002/1681 having supporting structure for lens, e.g. haptics
• CPC Class Codes: A61F 2230/0006 circular
• CPC Class Codes: B29C 33/123 for centering the inserts
• CPC Class Codes: B29D 11/00442 Curing the lens material
• CPC Class Codes: B29D 11/0048 Moulds for lenses moulds for plastic articles in general B29C33/00
• CPC Class Codes: B29D 11/023 Implants for natural eyes
• CPC Class Codes: B29K 2627/16 PVDF, i.e. polyvinylidene fluoride
• CPC Class Codes: B29K 2995/0093 hydrophobic

Abstract

Intraocular implants and methods of making intraocular implants are provided. The intraocular implant can include a mask adapted to increase depth of focus. The method of manufacturing the implant can include positioning the mask with an aperture on a protruding pin of a positioning mold portion. The protruding pin can be configured to center the mask in the intraocular lens.

Claims

1. A method of manufacturing an intraocular lens, the method comprising:

adding a first amount of a lens material to a first mold portion;

positioning a mask with an aperture on a shoulder portion of a protruding pin of a positioning mold portion, the shoulder portion configured to control a depth of the mask in the intraocular lens;

joining the first mold portion and the positioning mold portion; and

partially curing the first amount of the lens material.

2. The method of claim 1, wherein a diameter of the shoulder portion is larger than a diameter of the aperture of the mask.

3. The method of claim 1, wherein the shoulder portion extends from an interior surface of the positioning mold portion.

4. The method of claim 1, wherein joining the first mold portion and the positioning mold portion causes lens material to flow into a space between a surface of the mask and an inner surface of the positioning mold portion so as to at least partially surround the mask with lens material on both of its sides.

5. The method of claim 1, wherein the lens material comprises an ultraviolet light absorber and a light-sensitive initiator, the light-sensitive initiator being configured to cure the lens material when exposed to light having a wavelength outside the absorption spectrum of the ultraviolet light absorber.

6. The method of claim 5, wherein the light-sensitive initiator is configured to be activated by light having a wavelength in a range from about 380 nm to about 495 nm.

7. The method of claim 1, wherein partially curing the first amount of the lens material comprises applying light to the first mold portion.

8. The method of claim 1, wherein partially curing the first amount of the lens material comprises curing the first amount of the lens material to a sufficient degree that the mask remains with the first mold portion after removing the positioning mold portion.

9. The method of claim 1, further comprising cooling the first mold portion.

10. The method of claim 9, wherein cooling the first mold portion comprises cooling the first mold portion using a cryogenic fluid.

11. The method of claim 9, wherein cooling the first mold portion comprises reducing a temperature of the first mold portion by at least 20 degrees.

12. The method of claim 1, further comprising removing the positioning mold portion and joining the first mold portion and a second mold portion.

13. The method of claim 12, further comprising adding a second amount of the lens material to the second mold portion.

14. The method of claim 13, further comprising partially curing the second amount of the lens material by exposure to light.

15. The method of claim 14, further comprising, after partially curing the second amount of the lens material by exposure to light, thermally curing the second amount of the lens material.

16. The method of claim 15, further comprising polymerizing at least 99% of the first and second amounts of the lens material.

17. The method of claim 1, wherein the lens material is a hydrophobic material.

18. The method of claim 1, further comprising joining a haptic shield and the positioning mold such that the haptic shield prevents polymerization of the lens material in a haptic region.