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Procoagulant fusion compound

  • US 10,584,147 B2
  • Filed: 11/07/2014
  • Issued: 03/10/2020
  • Est. Priority Date: 11/08/2013
  • Status: Active Grant
First Claim
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1. A polynucleotide encoding a fusion compound of the structure P-L1-F1-L2-F2, the fusion compound comprising a procoagulant compound (P), a first immunoglobulin constant region or portion thereof (F1), and a second immunoglobulin constant region or portion thereof (F2),wherein P is linked through its C-terminal to the N-terminal of F1 with a first linker (L1) comprising an amino acid sequence as set forth in SEQ ID NO:

  • 22,wherein F1 is linked through its C-terminal to the N-terminal of F2 with a second linker (L2) comprising an amino acid sequence as set forth in SEQ ID NO;

    22, andwherein P comprises the amino acid sequence GSRIRTVSPGSRSASGKSTCLASYCWLFWTGIA (SEQ ID NO;

         4).

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