Multipurpose implant with modeled surface structure for soft tissue reconstruction

• US 10,588,732 B2
• Filed: 10/31/2016
• Issued: 03/17/2020
• Est. Priority Date: 03/07/2014
• Status: Active Grant

• Current Assignee: Iconlab USA, Inc.
• Original Assignee: Iconlab USA, Inc.
• Inventors: Agarkov, Viacheslav, Uspenskiy, Igor, Kolmogorov, Yury
• Primary Examiner(s): Ghali, Isis A
• Application Number:
  US15/339,805
• Publication Number:
  US 20170112607A1
• Time in Patent Office: 1,233 Days
• Field of Search: None
• CPC Class Codes: A61F 2/0063 Implantable repair or support meshes, e.g. hernia meshes
• CPC Class Codes: A61F 2/0077 Special surfaces of prostheses, e.g. for improving ingrowth A61F2/30767 takes precedence
• CPC Class Codes: A61F 2002/0081 directly machined on the prosthetic surface, e.g. holes, grooves A61F2/30771 takes precedence
• CPC Class Codes: A61F 2002/0086 for preferentially controlling or promoting the growth of specific types of cells or tissues of bone tissue onto implantable joints A61F2002/3093
• CPC Class Codes: A61F 2002/009 for hindering or preventing attachment of biological tissue of bone tissue onto implantable joints A61F2002/30932
• CPC Class Codes: A61F 2210/0076 multilayered, e.g. laminated structures
• CPC Class Codes: A61F 2230/0006 circular
• CPC Class Codes: A61F 2230/0021 square
• CPC Class Codes: A61F 2250/0018 differing in elasticity, stiffness or compressibility
• CPC Class Codes: A61F 2250/0025 differing in roughness
• CPC Class Codes: A61L 2400/18 Modification of implant surfaces in order to improve biocompatibility, cell growth, fixation of biomolecules, e.g. plasma treatment
• CPC Class Codes: A61L 2430/34 for soft tissue reconstruction
• CPC Class Codes: A61L 27/16 obtained by reactions only involving carbon-to-carbon unsaturated bonds
• CPC Class Codes: A61L 27/50 Materials characterised by their function or physical properties , e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
• CPC Class Codes: C08L 33/12 Homopolymers or copolymers of methyl methacrylate

Abstract

Embodiments of a multi-purpose implant for use in surgery, such as for reconstruction of soft tissues, are disclosed. In some embodiments, the implant includes elastic polymer film made from a suitable biologically compatible polymer. The implant also includes a reinforcement element forms from a polyurethane mesh or other strong and stable woven or unwoven synthetic material. The reinforcement element can be fully enclosed by the film so that only the film comes into contact with the organs and tissues. Anti-adhesive properties or control over implant'"'"'s integration into a body can be determined by the preset surface structure of the implant, while physical and mechanical properties, such as strength and elasticity of the implant, are obtained by virtue of reinforcement element geometry.

Claims

1. A multi-purpose surgical implant for reconstruction of soft tissues comprising:

an elastic film formed from a non-porous biologically compatible cross-linked copolymer based on 50-75 percent by weight multi-functional urethane (meth)acrylate oligomers and 20-50 percent by weight methacrylate monomers, the elastic film having;

a first smooth anti-adhesive surface, and

a second relief surface opposite the first surface;

wherein the elastic film is processed by soaking in isopropyl alcohol so as to block residual free radicals, thereby decreasing a risk of tissue reaction;

a reinforcement element partially enclosed inside the elastic film, wherein the reinforcement element does not contact body organs and tissue from the side of the first smooth anti-adhesive surface.

2. The multi-purpose surgical implant of claim 1, wherein the first smooth surface has a roughness that does not exceed about 50 nanometers.

3. The multi-purpose surgical implant of claim 1, wherein the elastic film is continuous without apertures such that the reinforcement element is covered with the film across the entire first smooth anti-adhesive surface area of the implant.

4. The multi-purpose surgical implant of claim 1, wherein the second relief surface comprises indentations shaped as cubic, prismatic, or truncated pyramidal with the same depth as a thickness of the elastic film from the reinforcement element to an outer edge of the second relief surface.

5. The multi-purpose surgical implant of claim 1, wherein the reinforcement element comprises a plurality of through holes to improve flexibility during implantation.

6. The multi-purpose surgical implant of claim 5, wherein the elastic film comprises through holes corresponding to the through holes of the reinforcement element such that the reinforcement element is covered by the elastic film across the entire first smooth anti-adhesive surface area of the implant.

7. The multi-purpose surgical implant of claim 1, wherein the reinforcement element comprises unwoven synthetic material.

8. The multi-purpose surgical implant of claim 1, wherein the reinforcement element comprises woven synthetic material.

9. The multi-purpose surgical implant of claim 1, wherein the reinforcement element comprises at least one of polyamide, polypropylene, polyethylene terephthalate, and polyvinylidene fluoride.

17. The multi-purpose surgical implant of claim 1, wherein the cross-linked copolymer comprises 50-70 weight percent of oligourethane methacrylate and 1-5 weight percent of octyl methacrylate.

18. The multi-purpose surgical implant of claim 17, wherein the second relief surface comprises an embossed pattern comprising at least one of mesh, numbers, and letters.

19. The multi-purpose surgical implant of claim 1, wherein the cross-linked copolymer comprises 55-75 weight percent of oligourethane methacrylate and 20-30 weight percent of phynoxyethyl methacrylate.

10. A multi-purpose surgical implant for reconstruction of soft tissues comprising:

a polymer elastic film formed from non-porous bio-compatible cross-linked copolymer based on 55-75 percent by weight multi-functional urethane (meth)acrylate oligomers and 22-40 percent by weight methacrylate monomers, where the polymer film has a first flat smooth anti-adhesive surface and a second relief surface opposite the first surface with truncated pyramid protrusions, wherein the polymer elastic film is soaked in isopropyl alcohol to block residual free radicals, thereby decreasing a risk of tissue reaction; and

a continuous reinforcement element partially enclosed inside the polymer elastic film, wherein the reinforcement element does not contact body organs and tissue from the side of the first smooth anti-adhesive surface.

11. The implant of claim 10, wherein the reinforcement element comprises cutouts to improve flexibility of the device during implantation.

12. The implant of claim 11, wherein the polymer elastic film has through holes in areas corresponding to the reinforcement element cutouts to keep the reinforcement element covered by polymer elastic film across the entire first smooth anti-adhesive surface area of the implant.

13. The implant of claim 12, wherein the reinforcement element comprises unwoven synthetic material configured to stabilize and strengthen the implant.

14. The implant of claim 12, wherein the reinforcement element comprises woven synthetic material configured to stabilize and strengthen the implant.

15. The implant of claim 10, wherein the reinforcement element comprises polypropylene.

16. The implant of claim 10, wherein the second relief surface of the polymer elastic film has areas where the protrusions are present and areas where the protrusion are not present form numbers, letters, and combinations thereof.