Polymeric treatment compositions
First Claim
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1. A method of treating a vascular condition comprising:
- guiding a delivery device to an area in need of treatment within a physiological environment;
injecting through the delivery device into the physiological environment a liquid embolic composition comprising a biocompatible polymer including a first monomer selected from a group consisting of aminopropyl methacrylamide, aminoethyl methacrylamide, aminoethyl methacylate, aminopropyl methacylate, N-(3-methylpyridine)acrylamide, N-(2-(4-aminophenyl)ethylacrylamide, N-(4-aminobenzyl)acrylamide, N-(2-4-imidazolyl)ethyl)acrylamide, and combinations thereof, a second monomer including an acrylate, acrylamide, a derivative thereof, or a combination thereof, an aqueous solution, and a visualization agent, wherein the visualization agent is an iodinated compound, barium sulfate tantalum, superparamagnetic iron oxide, gadolinium molecules, or a combination thereof, wherein the biocompatible polymer is soluble in the aqueous solution and insoluble in the physiological environment thereby immediately precipitating and forming a solid polymeric mass at the area in need of treatment; and
treating the vascular condition.
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Abstract
Compositions are described comprising a polymer; a non-physiological pH solution; and a visualization agent; wherein the polymer is soluble in the non-physiological pH solution and insoluble at a physiological pH. Methods of forming the solutions and polymers are disclosed as well as methods of therapeutic use.
183 Citations
6 Claims
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1. A method of treating a vascular condition comprising:
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guiding a delivery device to an area in need of treatment within a physiological environment; injecting through the delivery device into the physiological environment a liquid embolic composition comprising a biocompatible polymer including a first monomer selected from a group consisting of aminopropyl methacrylamide, aminoethyl methacrylamide, aminoethyl methacylate, aminopropyl methacylate, N-(3-methylpyridine)acrylamide, N-(2-(4-aminophenyl)ethylacrylamide, N-(4-aminobenzyl)acrylamide, N-(2-4-imidazolyl)ethyl)acrylamide, and combinations thereof, a second monomer including an acrylate, acrylamide, a derivative thereof, or a combination thereof, an aqueous solution, and a visualization agent, wherein the visualization agent is an iodinated compound, barium sulfate tantalum, superparamagnetic iron oxide, gadolinium molecules, or a combination thereof, wherein the biocompatible polymer is soluble in the aqueous solution and insoluble in the physiological environment thereby immediately precipitating and forming a solid polymeric mass at the area in need of treatment; and treating the vascular condition. - View Dependent Claims (2, 3, 4, 5, 6)
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Specification