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Endodermal cell production method, liver cell production method, pancreatic cell production method, endodermal cell induction promoter, liver cell induction promoting kit, pancreatic cell induction promoting kit, and microfluidic device

  • US 10,590,389 B2
  • Filed: 12/22/2015
  • Issued: 03/17/2020
  • Est. Priority Date: 12/24/2014
  • Status: Active Grant
First Claim
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1. A method for producing endodermal cells by inducing differentiation of pluripotent cells into the endodermal cells, the method comprising the step of:

  • inducing differentiation of the pluripotent cells into the endodermal cells in the presence of an endodermal cell inducing factor,wherein, in the inducing step, ROCK protein activity is inhibited, andthe endodermal cell inducing factor comprises a PI3K protein activity inhibitor.

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