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Chiral control

  • US 10,590,413 B2
  • Filed: 03/17/2017
  • Issued: 03/17/2020
  • Est. Priority Date: 07/13/2012
  • Status: Active Grant
First Claim
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1. A method for making a chirally controlled oligonucleotide comprising steps of:

  • (1) coupling;

    (2) capping;

    (3) modifying;

    (4) deblocking; and

    (5) repeating steps (1)-(4) until a desired length is achieved;

    wherein at least one cycle of (1) to (4) forms an internucleotidic linkage having the structure of formula I-c;

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