MicroRNA induction of cardiac regeneration
First Claim
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1. A method for promoting cardiac repair and regeneration in a subject, the method comprising:
- transiently administering locally to the heart of said subject a composition comprising a microRNA (miR) 302-367 cluster or a miR 302-367 cluster mimic, wherein said transient administration is sufficient to transiently activate cardiomyocyte proliferation, but not to persistently reactivate the cell cycle of postnatal cardiomyocytes.
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Abstract
The invention relates to compostions and methods for promoting cellular proliferation and de-differentiation of cells into stem cells to foster tissue regeneration. Specifically, the invention relates to transiently administering a microRNA (miR) or its mimic for promoting cardiomyocyte proliferation and cardiac regeneration.
8 Citations
13 Claims
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1. A method for promoting cardiac repair and regeneration in a subject, the method comprising:
- transiently administering locally to the heart of said subject a composition comprising a microRNA (miR) 302-367 cluster or a miR 302-367 cluster mimic, wherein said transient administration is sufficient to transiently activate cardiomyocyte proliferation, but not to persistently reactivate the cell cycle of postnatal cardiomyocytes.
- View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10)
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11. A method for promoting cardiac repair and regeneration in a subject, the method comprising:
- transiently administering locally to the heart of said subject a composition comprising a microRNA (miR) cluster or its mimic, wherein said cluster comprises one or more of miR302b and miR302c or two or more of miR302b, miR302c, and miR367, and wherein said transient administration is sufficient to transiently activate cardiomyocyte proliferation, but not to persistently reactivate the cell cycle of postnatal cardiomyocytes.
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12. A method for promoting cardiac repair and regeneration in a subject, the method comprising:
- transiently administering intravenously at least once daily for 7 days said subject a composition comprising a microRNA (miR) 302-367 cluster or a miR 302-367 cluster mimic, wherein said transient administration is sufficient to transiently activate cardiomyocyte proliferation, but not to persistently reactivate the cell cycle of postnatal cardiomyocytes.
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13. A method for promoting cardiac repair and regeneration in a subject, the method comprising:
- transiently administering intravenously at least once daily for 7 days said subject a composition comprising a microRNA (miR) cluster or its mimic, wherein said cluster comprises one or more of miR302b and miR302c or two or more of miR302b, miR302c, and miR367, and wherein said transient administration is sufficient to transiently activate cardiomyocyte proliferation, but not to persistently reactivate the cell cycle of postnatal cardiomyocytes.
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